Nerve growth factor is elevated in the CSF of patients with multiple sclerosis and central neuropathic pain

Fabrizia Monteleone, Carolina G. Nicoletti, Mario Stampanoni Bassi, Ennio Iezzi, Fabio Buttari, Roberto Furlan, Annamaria Finardi, Girolama A. Marfia, Diego Centonze, Francesco Mori

Research output: Contribution to journalArticlepeer-review

Abstract

Central neuropathic pain (CNP) is common and disabling among patients with multiple sclerosis (MS). The pathological mechanisms underlying CNP in MS are not well understood. We explored whether NGF is implicated in the pathogenesis of CNP in MS. We measured NGF concentration in the CSF of 73 patients affected by MS, 15 with and 58 without CNP and 14 controls. We found increased levels of NGF in the CSF of patients with CNP compared to patients without and to controls. This finding supports the hypothesis that NGF plays a role in MS related CNP.

Original languageEnglish
Pages (from-to)89-93
Number of pages5
JournalJournal of Neuroimmunology
Volume314
DOIs
Publication statusPublished - Jan 15 2018

Keywords

  • Inflammation
  • MS
  • Nerve growth factor
  • Neurotrophins

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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