Nerve growth factor is elevated in the CSF of patients with multiple sclerosis and central neuropathic pain

Fabrizia Monteleone; Carolina G. Nicoletti; Mario Stampanoni Bassi; Ennio Iezzi; Fabio Buttari; Roberto Furlan; Annamaria Finardi; Girolama A. Marfia; Diego Centonze; Francesco Mori

doi:10.1016/j.jneuroim.2017.11.012

Nerve growth factor is elevated in the CSF of patients with multiple sclerosis and central neuropathic pain

Fabrizia Monteleone, Carolina G. Nicoletti, Mario Stampanoni Bassi, Ennio Iezzi, Fabio Buttari, Roberto Furlan, Annamaria Finardi, Girolama A. Marfia, Diego Centonze, Francesco Mori

Research output: Contribution to journal › Article › peer-review

Abstract

Central neuropathic pain (CNP) is common and disabling among patients with multiple sclerosis (MS). The pathological mechanisms underlying CNP in MS are not well understood. We explored whether NGF is implicated in the pathogenesis of CNP in MS. We measured NGF concentration in the CSF of 73 patients affected by MS, 15 with and 58 without CNP and 14 controls. We found increased levels of NGF in the CSF of patients with CNP compared to patients without and to controls. This finding supports the hypothesis that NGF plays a role in MS related CNP.

Original language	English
Pages (from-to)	89-93
Number of pages	5
Journal	Journal of Neuroimmunology
Volume	314
DOIs	https://doi.org/10.1016/j.jneuroim.2017.11.012
Publication status	Published - Jan 15 2018

Keywords

Inflammation
MS
Nerve growth factor
Neurotrophins

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

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Nerve growth factor is elevated in the CSF of patients with multiple sclerosis and central neuropathic pain. / Monteleone, Fabrizia; Nicoletti, Carolina G.; Stampanoni Bassi, Mario ; Iezzi, Ennio ; Buttari, Fabio ; Furlan, Roberto; Finardi, Annamaria; Marfia, Girolama A.; Centonze, Diego; Mori, Francesco.

In: Journal of Neuroimmunology, Vol. 314, 15.01.2018, p. 89-93.

Research output: Contribution to journal › Article › peer-review

Monteleone, Fabrizia ; Nicoletti, Carolina G. ; Stampanoni Bassi, Mario ; Iezzi, Ennio ; Buttari, Fabio ; Furlan, Roberto ; Finardi, Annamaria ; Marfia, Girolama A. ; Centonze, Diego ; Mori, Francesco. / Nerve growth factor is elevated in the CSF of patients with multiple sclerosis and central neuropathic pain. In: Journal of Neuroimmunology. 2018 ; Vol. 314. pp. 89-93.

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abstract = "Central neuropathic pain (CNP) is common and disabling among patients with multiple sclerosis (MS). The pathological mechanisms underlying CNP in MS are not well understood. We explored whether NGF is implicated in the pathogenesis of CNP in MS. We measured NGF concentration in the CSF of 73 patients affected by MS, 15 with and 58 without CNP and 14 controls. We found increased levels of NGF in the CSF of patients with CNP compared to patients without and to controls. This finding supports the hypothesis that NGF plays a role in MS related CNP.",

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AU - Monteleone, Fabrizia

AU - Nicoletti, Carolina G.

AU - Stampanoni Bassi, Mario

AU - Iezzi, Ennio

AU - Buttari, Fabio

AU - Furlan, Roberto

AU - Finardi, Annamaria

AU - Marfia, Girolama A.

AU - Centonze, Diego

AU - Mori, Francesco

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N2 - Central neuropathic pain (CNP) is common and disabling among patients with multiple sclerosis (MS). The pathological mechanisms underlying CNP in MS are not well understood. We explored whether NGF is implicated in the pathogenesis of CNP in MS. We measured NGF concentration in the CSF of 73 patients affected by MS, 15 with and 58 without CNP and 14 controls. We found increased levels of NGF in the CSF of patients with CNP compared to patients without and to controls. This finding supports the hypothesis that NGF plays a role in MS related CNP.

AB - Central neuropathic pain (CNP) is common and disabling among patients with multiple sclerosis (MS). The pathological mechanisms underlying CNP in MS are not well understood. We explored whether NGF is implicated in the pathogenesis of CNP in MS. We measured NGF concentration in the CSF of 73 patients affected by MS, 15 with and 58 without CNP and 14 controls. We found increased levels of NGF in the CSF of patients with CNP compared to patients without and to controls. This finding supports the hypothesis that NGF plays a role in MS related CNP.

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KW - MS

KW - Nerve growth factor

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