TY - JOUR
T1 - Nerve growth factor is elevated in the CSF of patients with multiple sclerosis and central neuropathic pain
AU - Monteleone, Fabrizia
AU - Nicoletti, Carolina G.
AU - Stampanoni Bassi, Mario
AU - Iezzi, Ennio
AU - Buttari, Fabio
AU - Furlan, Roberto
AU - Finardi, Annamaria
AU - Marfia, Girolama A.
AU - Centonze, Diego
AU - Mori, Francesco
PY - 2018/1/15
Y1 - 2018/1/15
N2 - Central neuropathic pain (CNP) is common and disabling among patients with multiple sclerosis (MS). The pathological mechanisms underlying CNP in MS are not well understood. We explored whether NGF is implicated in the pathogenesis of CNP in MS. We measured NGF concentration in the CSF of 73 patients affected by MS, 15 with and 58 without CNP and 14 controls. We found increased levels of NGF in the CSF of patients with CNP compared to patients without and to controls. This finding supports the hypothesis that NGF plays a role in MS related CNP.
AB - Central neuropathic pain (CNP) is common and disabling among patients with multiple sclerosis (MS). The pathological mechanisms underlying CNP in MS are not well understood. We explored whether NGF is implicated in the pathogenesis of CNP in MS. We measured NGF concentration in the CSF of 73 patients affected by MS, 15 with and 58 without CNP and 14 controls. We found increased levels of NGF in the CSF of patients with CNP compared to patients without and to controls. This finding supports the hypothesis that NGF plays a role in MS related CNP.
KW - Inflammation
KW - MS
KW - Nerve growth factor
KW - Neurotrophins
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U2 - 10.1016/j.jneuroim.2017.11.012
DO - 10.1016/j.jneuroim.2017.11.012
M3 - Article
AN - SCOPUS:85034787639
VL - 314
SP - 89
EP - 93
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
SN - 0165-5728
ER -