Nerve growth factor is elevated in the CSF of patients with multiple sclerosis and central neuropathic pain

Fabrizia Monteleone, CG Nicoletti, M Stampanoni Bassi, E Iezzi, F Buttari, R Furlan, A Finardi, GA Marfia, D Centonze, Francesco Mori

Research output: Contribution to journalArticle

Abstract

Central neuropathic pain (CNP) is common and disabling among patients with multiple sclerosis (MS). The pathological mechanisms underlying CNP in MS are not well understood. We explored whether NGF is implicated in the pathogenesis of CNP in MS. We measured NGF concentration in the CSF of 73 patients affected by MS, 15 with and 58 without CNP and 14 controls. We found increased levels of NGF in the CSF of patients with CNP compared to patients without and to controls. This finding supports the hypothesis that NGF plays a role in MS related CNP. © 2017 Elsevier B.V.
Original languageEnglish
Pages (from-to)89-93
Number of pages5
JournalJournal of Neuroimmunology
Volume314
Issue number5
DOIs
Publication statusPublished - 2018

Fingerprint Dive into the research topics of 'Nerve growth factor is elevated in the CSF of patients with multiple sclerosis and central neuropathic pain'. Together they form a unique fingerprint.

Cite this