Nerve growth factor promotes reparative angiogenesis and inhibits endothelial apoptosis in cutaneous wounds of Type 1 diabetic mice

G. Graiani, C. Emanueli, E. Desortes, S. Van Linthout, A. Pinna, C. D. Figueroa, L. Manni, P. Madeddu

Research output: Contribution to journalArticlepeer-review

Abstract

Aims/hypothesis. The neurotrophin nerve growth factor (NGF) is pro-angiogenic and facilitates wound repair. The present study was conducted to (i) assess the statement of NGF system components in diabetic wounds and (ii) evaluate whether NGF supplementation could prevent impairment of wound neoangiogenesis by diabetes. Methods. Skin wounds were produced in the interscapular region of streptozotocin-induced diabetic mice. NGF (1 μg per day in PBS) or vehicle was applied onto the ulcers for 3 days after punching. Non-diabetic mice were used as controls. Results. In wounds of untreated diabetic mice, endogenous levels of immunoreactive NGF were lower than those in wounds of non-diabetic mice (p

Original languageEnglish
Pages (from-to)1047-1054
Number of pages8
JournalDiabetologia
Volume47
Issue number6
Publication statusPublished - Jun 2004

Keywords

  • Angiogenesis
  • Apoptosis
  • Diabetes
  • Vascular growth factor
  • Wound healing

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

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