Nerve growth factor promotes reparative angiogenesis and inhibits endothelial apoptosis in cutaneous wounds of Type 1 diabetic mice

G. Graiani; C. Emanueli; E. Desortes; S. Van Linthout; A. Pinna; C. D. Figueroa; L. Manni; P. Madeddu

Nerve growth factor promotes reparative angiogenesis and inhibits endothelial apoptosis in cutaneous wounds of Type 1 diabetic mice

G. Graiani, C. Emanueli, E. Desortes, S. Van Linthout, A. Pinna, C. D. Figueroa, L. Manni, P. Madeddu

IRCCS Multimedica

Research output: Contribution to journal › Article › peer-review

Abstract

Aims/hypothesis. The neurotrophin nerve growth factor (NGF) is pro-angiogenic and facilitates wound repair. The present study was conducted to (i) assess the statement of NGF system components in diabetic wounds and (ii) evaluate whether NGF supplementation could prevent impairment of wound neoangiogenesis by diabetes. Methods. Skin wounds were produced in the interscapular region of streptozotocin-induced diabetic mice. NGF (1 μg per day in PBS) or vehicle was applied onto the ulcers for 3 days after punching. Non-diabetic mice were used as controls. Results. In wounds of untreated diabetic mice, endogenous levels of immunoreactive NGF were lower than those in wounds of non-diabetic mice (p

Original language	English
Pages (from-to)	1047-1054
Number of pages	8
Journal	Diabetologia
Volume	47
Issue number	6
Publication status	Published - Jun 2004

Keywords

Angiogenesis
Apoptosis
Diabetes
Vascular growth factor
Wound healing

ASJC Scopus subject areas

Internal Medicine
Endocrinology, Diabetes and Metabolism

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title = "Nerve growth factor promotes reparative angiogenesis and inhibits endothelial apoptosis in cutaneous wounds of Type 1 diabetic mice",

abstract = "Aims/hypothesis. The neurotrophin nerve growth factor (NGF) is pro-angiogenic and facilitates wound repair. The present study was conducted to (i) assess the statement of NGF system components in diabetic wounds and (ii) evaluate whether NGF supplementation could prevent impairment of wound neoangiogenesis by diabetes. Methods. Skin wounds were produced in the interscapular region of streptozotocin-induced diabetic mice. NGF (1 μg per day in PBS) or vehicle was applied onto the ulcers for 3 days after punching. Non-diabetic mice were used as controls. Results. In wounds of untreated diabetic mice, endogenous levels of immunoreactive NGF were lower than those in wounds of non-diabetic mice (p",

keywords = "Angiogenesis, Apoptosis, Diabetes, Vascular growth factor, Wound healing",

author = "G. Graiani and C. Emanueli and E. Desortes and {Van Linthout}, S. and A. Pinna and Figueroa, {C. D.} and L. Manni and P. Madeddu",

year = "2004",

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T1 - Nerve growth factor promotes reparative angiogenesis and inhibits endothelial apoptosis in cutaneous wounds of Type 1 diabetic mice

AU - Graiani, G.

AU - Emanueli, C.

AU - Desortes, E.

AU - Van Linthout, S.

AU - Pinna, A.

AU - Figueroa, C. D.

AU - Manni, L.

AU - Madeddu, P.

PY - 2004/6

Y1 - 2004/6

N2 - Aims/hypothesis. The neurotrophin nerve growth factor (NGF) is pro-angiogenic and facilitates wound repair. The present study was conducted to (i) assess the statement of NGF system components in diabetic wounds and (ii) evaluate whether NGF supplementation could prevent impairment of wound neoangiogenesis by diabetes. Methods. Skin wounds were produced in the interscapular region of streptozotocin-induced diabetic mice. NGF (1 μg per day in PBS) or vehicle was applied onto the ulcers for 3 days after punching. Non-diabetic mice were used as controls. Results. In wounds of untreated diabetic mice, endogenous levels of immunoreactive NGF were lower than those in wounds of non-diabetic mice (p

AB - Aims/hypothesis. The neurotrophin nerve growth factor (NGF) is pro-angiogenic and facilitates wound repair. The present study was conducted to (i) assess the statement of NGF system components in diabetic wounds and (ii) evaluate whether NGF supplementation could prevent impairment of wound neoangiogenesis by diabetes. Methods. Skin wounds were produced in the interscapular region of streptozotocin-induced diabetic mice. NGF (1 μg per day in PBS) or vehicle was applied onto the ulcers for 3 days after punching. Non-diabetic mice were used as controls. Results. In wounds of untreated diabetic mice, endogenous levels of immunoreactive NGF were lower than those in wounds of non-diabetic mice (p

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KW - Apoptosis

KW - Diabetes

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KW - Wound healing

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