Abstract
Aims/hypothesis. The neurotrophin nerve growth factor (NGF) is pro-angiogenic and facilitates wound repair. The present study was conducted to (i) assess the statement of NGF system components in diabetic wounds and (ii) evaluate whether NGF supplementation could prevent impairment of wound neoangiogenesis by diabetes. Methods. Skin wounds were produced in the interscapular region of streptozotocin-induced diabetic mice. NGF (1 μg per day in PBS) or vehicle was applied onto the ulcers for 3 days after punching. Non-diabetic mice were used as controls. Results. In wounds of untreated diabetic mice, endogenous levels of immunoreactive NGF were lower than those in wounds of non-diabetic mice (p
Original language | English |
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Pages (from-to) | 1047-1054 |
Number of pages | 8 |
Journal | Diabetologia |
Volume | 47 |
Issue number | 6 |
Publication status | Published - Jun 2004 |
Keywords
- Angiogenesis
- Apoptosis
- Diabetes
- Vascular growth factor
- Wound healing
ASJC Scopus subject areas
- Internal Medicine
- Endocrinology, Diabetes and Metabolism