Nerve growth factor signaling in prostate health and disease

Nicola Arrighi, Serena Bodei, Danilo Zani, Claudio Simeone, Sergio Cosciani Cunico, Cristina Missale, Pierfranco Spano, Sandra Sigala

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

The prostate is one of the most abundant sources of nerve growth factor (NGF) in different species, including humans. NGF and its receptors are implicated in the control of prostate cell proliferation and apoptosis and it can either support or suppress cell growth. The co-expression of both NGF receptors, p75NGFR and tropomyosin-related kinase A (trkA), represents a crucial condition for the antiproliferative effect of NGF; indeed, p75NGFR is progressively lost during prostate tumorigenesis and its disappearance represents a malignancy marker of prostate adenocarcinoma (PCa). Interestingly, a dysregulation of NGF signal transduction was found in a number of human tumors.This review summarizes the current knowledge on the role of NGF and its receptors in prostate and in PCa. Conclusions bring to the hypothesis that the NGF network could be a candidate for future pharmacological manipulation in the PCa therapy: in particular the re-expression of p75 NTR and/or the negative modulation of trkA could represent a target to induce apoptosis and to reduce proliferation and invasiveness of PCa.

Original languageEnglish
Pages (from-to)191-201
Number of pages11
JournalGrowth Factors
Volume28
Issue number3
DOIs
Publication statusPublished - Jun 2010

Fingerprint

Nerve Growth Factor
Nerve Growth Factor Receptors
Prostate
Health
Tropomyosin
Adenocarcinoma
Phosphotransferases
Apoptosis
Signal transduction
Cell proliferation
Cell growth
Tumors
Modulation
Signal Transduction
Neoplasms
Carcinogenesis
Cell Proliferation
Pharmacology
Growth

Keywords

  • Cancer
  • Nerve growth factor
  • Nerve growth factor receptors
  • Prostate

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Endocrinology
  • Cell Biology

Cite this

Arrighi, N., Bodei, S., Zani, D., Simeone, C., Cunico, S. C., Missale, C., ... Sigala, S. (2010). Nerve growth factor signaling in prostate health and disease. Growth Factors, 28(3), 191-201. https://doi.org/10.3109/08977190903578678

Nerve growth factor signaling in prostate health and disease. / Arrighi, Nicola; Bodei, Serena; Zani, Danilo; Simeone, Claudio; Cunico, Sergio Cosciani; Missale, Cristina; Spano, Pierfranco; Sigala, Sandra.

In: Growth Factors, Vol. 28, No. 3, 06.2010, p. 191-201.

Research output: Contribution to journalArticle

Arrighi, N, Bodei, S, Zani, D, Simeone, C, Cunico, SC, Missale, C, Spano, P & Sigala, S 2010, 'Nerve growth factor signaling in prostate health and disease', Growth Factors, vol. 28, no. 3, pp. 191-201. https://doi.org/10.3109/08977190903578678
Arrighi N, Bodei S, Zani D, Simeone C, Cunico SC, Missale C et al. Nerve growth factor signaling in prostate health and disease. Growth Factors. 2010 Jun;28(3):191-201. https://doi.org/10.3109/08977190903578678
Arrighi, Nicola ; Bodei, Serena ; Zani, Danilo ; Simeone, Claudio ; Cunico, Sergio Cosciani ; Missale, Cristina ; Spano, Pierfranco ; Sigala, Sandra. / Nerve growth factor signaling in prostate health and disease. In: Growth Factors. 2010 ; Vol. 28, No. 3. pp. 191-201.
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