Nerve regenerative effects of GABA-B ligands in a model of neuropathic pain

Valerio Magnaghi, Luca Franco Castelnovo, Alessandro Faroni, Erica Cavalli, Lucia Caffino, Alessandra Colciago, Patrizia Procacci, Giorgio Pajardi

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Neuropathic pain arises as a direct consequence of a lesion or disease affecting the peripheral somatosensory system. It may be associated with allodynia and increased pain sensitivity. Few studies correlated neuropathic pain with nerve morphology and myelin proteins expression. Our aim was to test if neuropathic pain is related to nerve degeneration, speculating whether the modulation of peripheral GABA-B receptors may promote nerve regeneration and decrease neuropathic pain. We used the partial sciatic ligation- (PSL-) induced neuropathic model. The biochemical, morphological, and behavioural outcomes of sciatic nerve were analysed following GABA-B ligands treatments. Simultaneous 7-days coadministration of baclofen (10 mg/kg) and CGP56433 (3 mg/kg) alters tactile hypersensitivity. Concomitantly, specific changes of peripheral nerve morphology, nerve structure, and myelin proteins (P0 and PMP22) expression were observed. Nerve macrophage recruitment decreased and step coordination was improved. The PSL-induced changes in nociception correlate with altered nerve morphology and myelin protein expression. Peripheral synergic effects, via GABA-B receptor activation, promote nerve regeneration and likely ameliorate neuropathic pain.

Original languageEnglish
Article number368678
JournalBioMed Research International
Volume2014
DOIs
Publication statusPublished - 2014

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Neuralgia
gamma-Aminobutyric Acid
GABA-B Receptors
Myelin Proteins
Ligands
Myelin P0 Protein
Nerve Regeneration
Baclofen
Macrophages
Ligation
Nerve Degeneration
Chemical activation
Modulation
Nociception
Hyperalgesia
Touch
Sciatic Nerve
Peripheral Nerves
Hypersensitivity
Pain

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Medicine(all)

Cite this

Magnaghi, V., Castelnovo, L. F., Faroni, A., Cavalli, E., Caffino, L., Colciago, A., ... Pajardi, G. (2014). Nerve regenerative effects of GABA-B ligands in a model of neuropathic pain. BioMed Research International, 2014, [368678]. https://doi.org/10.1155/2014/368678

Nerve regenerative effects of GABA-B ligands in a model of neuropathic pain. / Magnaghi, Valerio; Castelnovo, Luca Franco; Faroni, Alessandro; Cavalli, Erica; Caffino, Lucia; Colciago, Alessandra; Procacci, Patrizia; Pajardi, Giorgio.

In: BioMed Research International, Vol. 2014, 368678, 2014.

Research output: Contribution to journalArticle

Magnaghi, V, Castelnovo, LF, Faroni, A, Cavalli, E, Caffino, L, Colciago, A, Procacci, P & Pajardi, G 2014, 'Nerve regenerative effects of GABA-B ligands in a model of neuropathic pain', BioMed Research International, vol. 2014, 368678. https://doi.org/10.1155/2014/368678
Magnaghi V, Castelnovo LF, Faroni A, Cavalli E, Caffino L, Colciago A et al. Nerve regenerative effects of GABA-B ligands in a model of neuropathic pain. BioMed Research International. 2014;2014. 368678. https://doi.org/10.1155/2014/368678
Magnaghi, Valerio ; Castelnovo, Luca Franco ; Faroni, Alessandro ; Cavalli, Erica ; Caffino, Lucia ; Colciago, Alessandra ; Procacci, Patrizia ; Pajardi, Giorgio. / Nerve regenerative effects of GABA-B ligands in a model of neuropathic pain. In: BioMed Research International. 2014 ; Vol. 2014.
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