Nerve-sparing versus conventional laparoscopic radical hysterectomy a minimum 12 months' follow-up study

Giorgio Bogani, Antonella Cromi, Stefano Uccella, Maurizio Serati, Jvan Casarin, Ciro Pinelli, Federica Nardelli, Fabio Ghezzi

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: The objective of this study was to determinatewhether the introduction of nerve-sparing (NS) procedure influences surgical and survival outcomes of cervical cancer patients undergoing laparoscopic radical hysterectomy (LRH). Methods: Data of consecutive patients undergoing minimally invasive radical with or without NS surgery for cervical cancer were enrolled in the study. Results: Sixty-three patients (66%) who had LRH were compared with 33 women (34%) undergoing NS-LRH. Among the NS group, 19 patients (57.6%) had surgery via minilaparoscopy (using 3-mm instruments). Baseline characteristics were similar between groups. Patients undergoing NS-LRH had shorter operative time (210 vs 257 minutes; P = 0.005) and higher number of pelvic lymph nodes yielded (29 [26-38] vs 22 [8Y49]; P <0.001) than patient in the control group. No differences in blood loss, complications, and parametrial width were observed. Patients were catheterized with an indwelling Foley catheter for a median of 3.5 days (2-7 days) and 5.5 days (4-7 days) in NS and non-NS groups, respectively (P = 0.01).Voiding dysfunctions occurred in 1 patient (3%) and 12 patients (19%) who underwent NS-LRH and standard LRH, respectively (P = 0.03). No differences in 3-year disease-free survival (P = 0.72) and overall survival (P = 0.71) were recorded. Conclusions: The beneficial effects (in terms of operative time and number of nodes harvested) of NS-LRH are likely determined by the expertise of the surgeon because NS approach was introduced after having acquired adequate background in conventional LRH. Our data show that in experienced hands NS-LRH is safe and feasible. Moreover, NS technique reduces catheterization time and the rate of postoperative urinary dysfunction.

Original languageEnglish
Pages (from-to)787-793
Number of pages7
JournalInternational Journal of Gynecological Cancer
Volume24
Issue number4
DOIs
Publication statusPublished - 2014

Keywords

  • Cervical cancer
  • Laparoscopy
  • Nerve-sparing
  • Radical hysterectomy
  • Survival

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Oncology
  • Medicine(all)

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