Nervous system ganglioside composition of normothermic and hibernating dormice (Glis glis)

Sandro Sonnino, Riccardo Ghidoni, Anna Malesci, Guido Tettamanti, Jurgen Marx, Reinhard Hilbig, Hinrich Rahmann

Research output: Contribution to journalArticle

Abstract

The ganglioside pattern of seven different regions, olfactory bulb, forebrain cortex, midbrain (corpora quadrigemina), cerebellum, brain stem, pons and spinal cord, of nervous system of normothermic and hibernating dormice (Glis glis) were investigated by two dimensional thin layer chromatography and densitometric quantification. Up to thirty different ganglioside spots were resolved, fifteen of which belonging to alkali labile species. Alkali labile gangliosides were present in all the regions obtained from normothermic animals, and their content, expressed as percentage of total ganglioside-bound sialic acid, ranged from a minimum of 10.2% in olfactory bulb, to a maximum of 30.1% in spinal cord. The most abundant alkali labile gangliosides were O-Ac-GT1b, O-Ac-GQ1b and an unidentified one, we coded I3. Alkali labile gangliosides were practically undetectable in hibernating dormice. They could be recognized only in brain stem, 3.3% and olfactory bulb, 0.6%.

Original languageEnglish
Pages (from-to)677-683
Number of pages7
JournalNeurochemistry International
Volume6
Issue number5
DOIs
Publication statusPublished - 1984

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Cellular and Molecular Neuroscience

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    Sonnino, S., Ghidoni, R., Malesci, A., Tettamanti, G., Marx, J., Hilbig, R., & Rahmann, H. (1984). Nervous system ganglioside composition of normothermic and hibernating dormice (Glis glis). Neurochemistry International, 6(5), 677-683. https://doi.org/10.1016/0197-0186(84)90049-4