TY - JOUR
T1 - Nestin Expression in Spitzoid Lesions
T2 - An Immunohistochemical Characterization with Clinical and Dermoscopic Correlations
AU - Guanziroli, Elena
AU - Del Gobbo, Alessandro
AU - Coggi, Antonella
AU - Venegoni, Luigia
AU - Fanoni, Daniele
AU - Ercoli, Giulia
AU - Boggio, Francesca
AU - Veraldi, Stefano
AU - Cavicchini, Stefano
AU - Berti, Emilio
AU - Ferrero, Stefano
AU - Gianotti, Raffaele
PY - 2019
Y1 - 2019
N2 - Spindle or epithelioid melanocytic (Spitz) nevi usually affect children or adolescents and growth in the face or the lower extremities. Histologically, they may show cytoarchitectural atypia and mitotic figures that could represent diagnostic pitfalls with malignant melanoma. Atypical spitzoid tumors (AST) indicate lesions that microscopically show intermediate characteristics between benign nevi and malignant melanoma. Nestin expression has been evaluated in benign nevi and malignant melanoma, but no studies on its role in Spitz lesion have been elaborated so far. Our results indicate that Nestin could allow to discriminate between AST and malignant spiztoid melanoma; the typical dermoscopic pattern is also associated with benign nevi in contrast to the atypical pattern that accumunates AST and malignant spitzoid melanoma.
AB - Spindle or epithelioid melanocytic (Spitz) nevi usually affect children or adolescents and growth in the face or the lower extremities. Histologically, they may show cytoarchitectural atypia and mitotic figures that could represent diagnostic pitfalls with malignant melanoma. Atypical spitzoid tumors (AST) indicate lesions that microscopically show intermediate characteristics between benign nevi and malignant melanoma. Nestin expression has been evaluated in benign nevi and malignant melanoma, but no studies on its role in Spitz lesion have been elaborated so far. Our results indicate that Nestin could allow to discriminate between AST and malignant spiztoid melanoma; the typical dermoscopic pattern is also associated with benign nevi in contrast to the atypical pattern that accumunates AST and malignant spitzoid melanoma.
KW - immunohistochemistry
KW - melanoma
KW - nestin
KW - Spitz nevi
UR - http://www.scopus.com/inward/record.url?scp=85053856526&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85053856526&partnerID=8YFLogxK
U2 - 10.1097/PAI.0000000000000653
DO - 10.1097/PAI.0000000000000653
M3 - Article
AN - SCOPUS:85053856526
VL - 27
SP - 430
EP - 435
JO - Applied Immunohistochemistry
JF - Applied Immunohistochemistry
SN - 1541-2016
IS - 6
ER -