Netilmicin effect on urinary Retinol Binding Protein (RBP) and N-acetyl-Beta-D-glucosaminidase (NAG) in preterm newborns with and without anoxia

L. Cataldi, M. Mussap, G. Verlato, M. Plebani, Vassilios Fanos

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The study aim was to evaluate urinary excretion of Retinol Binding Protein (RBP), compared with urinary excretion of N-acetyl-β-D-glucosaminidase (NAG), in preterm infants with anoxia and netilmicin treatment. Urinary RBP and NAG were evaluated in 83 preterm newborns divided in 4 groups: 37 healthy preterm newborns (controls); 14 with neonatal anoxia; 16 treated with ampicillin + netilmicin; 16 with neonatal anoxia and treated with ampicillin + netilmicin. RBP was determined by an automated nephelometric technique and NAG by a colorimetric method on 5-h urine samples in the first week of life. Results showed that urinary excretion of RBP (average from first week values) was 1.06±0.67 g/mol creatinine (mean ± SD) in controls, 1.99±1.41 in antibiotic-treated newborns, 3.99±4.57 in anoxic newborns and 3.75±3.48 in anoxic newborns under antibiotic treatment. When gestational age was not considered, a marked effect of anoxia (P

Original languageEnglish
Pages (from-to)76-83
Number of pages8
JournalJournal of Chemotherapy
Volume14
Issue number1
Publication statusPublished - 2002

Fingerprint

Netilmicin
Retinol-Binding Proteins
Acetylglucosaminidase
Newborn Infant
Ampicillin
Anti-Bacterial Agents
Hexosaminidases
Premature Infants
Gestational Age
Creatinine
Hypoxia
Urine
Therapeutics

Keywords

  • Anoxia
  • Gestational age
  • Netilmicin
  • Preterm newborns
  • Retinol Binding Protein
  • Urine

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Microbiology (medical)

Cite this

Netilmicin effect on urinary Retinol Binding Protein (RBP) and N-acetyl-Beta-D-glucosaminidase (NAG) in preterm newborns with and without anoxia. / Cataldi, L.; Mussap, M.; Verlato, G.; Plebani, M.; Fanos, Vassilios.

In: Journal of Chemotherapy, Vol. 14, No. 1, 2002, p. 76-83.

Research output: Contribution to journalArticle

Cataldi, L. ; Mussap, M. ; Verlato, G. ; Plebani, M. ; Fanos, Vassilios. / Netilmicin effect on urinary Retinol Binding Protein (RBP) and N-acetyl-Beta-D-glucosaminidase (NAG) in preterm newborns with and without anoxia. In: Journal of Chemotherapy. 2002 ; Vol. 14, No. 1. pp. 76-83.
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