Netilmicin effect on urinary Retinol Binding Protein (RBP) and N-acetyl-Beta-D-glucosaminidase (NAG) in preterm newborns with and without anoxia

L. Cataldi, M. Mussap, G. Verlato, M. Plebani, Vassilios Fanos

Research output: Contribution to journalArticlepeer-review

Abstract

The study aim was to evaluate urinary excretion of Retinol Binding Protein (RBP), compared with urinary excretion of N-acetyl-β-D-glucosaminidase (NAG), in preterm infants with anoxia and netilmicin treatment. Urinary RBP and NAG were evaluated in 83 preterm newborns divided in 4 groups: 37 healthy preterm newborns (controls); 14 with neonatal anoxia; 16 treated with ampicillin + netilmicin; 16 with neonatal anoxia and treated with ampicillin + netilmicin. RBP was determined by an automated nephelometric technique and NAG by a colorimetric method on 5-h urine samples in the first week of life. Results showed that urinary excretion of RBP (average from first week values) was 1.06±0.67 g/mol creatinine (mean ± SD) in controls, 1.99±1.41 in antibiotic-treated newborns, 3.99±4.57 in anoxic newborns and 3.75±3.48 in anoxic newborns under antibiotic treatment. When gestational age was not considered, a marked effect of anoxia (P

Original languageEnglish
Pages (from-to)76-83
Number of pages8
JournalJournal of Chemotherapy
Volume14
Issue number1
Publication statusPublished - 2002

Keywords

  • Anoxia
  • Gestational age
  • Netilmicin
  • Preterm newborns
  • Retinol Binding Protein
  • Urine

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Microbiology (medical)

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