Network based statistical analysis detects changes induced by continuous theta-burst stimulation on brain activity at rest

Chiara Mastropasqua, Marco Bozzali, Viviana Ponzo, Giovanni Giulietti, Carlo Caltagirone, Mara Cercignani, Giacomo Koch

Research output: Contribution to journalArticlepeer-review

Abstract

We combined continuous theta-burst stimulation (cTBS) and resting state (RS)-fMRI approaches to investigate changes in functional connectivity (FC) induced by right dorsolateral prefrontal cortex (DLPFC)-cTBS at rest in a group of healthy subjects. Seed-based fMRI analysis revealed a specific pattern of correlation between the right prefrontal cortex and several brain regions: based on these results, we defined a 29-node network to assess changes in each network connection before and after, respectively, DLPFC-cTBS and sham sessions. A decrease of correlation between the right prefrontal cortex and right parietal cortex (Brodmann areas 46 and 40, respectively) was detected after cTBS, while no significant result was found when analyzing sham-session data. To our knowledge, this is the first study that demonstrates within-subject changes in FC induced by cTBS applied on prefrontal area. The possibility to induce selective changes in a specific region without interfering with functionally correlated area could have several implications for the study of functional properties of the brain, and for the emerging therapeutic strategies based on transcranial stimulation.

Original languageEnglish
Article number97
JournalFrontiers in Psychiatry
Volume5
Issue numberAUG
DOIs
Publication statusPublished - 2014

Keywords

  • cTBS
  • Dorsolateral prefrontal cortex
  • Fronto-parietal network
  • Functional connectivity
  • Resting state fMRI

ASJC Scopus subject areas

  • Psychiatry and Mental health

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