Abstract
Objective: To investigate the changes in EEG connectivity in children with the typical presentation of benign epilepsy with centro-temporal spikes (BECTS). Methods: We compared awake and spindle-sleep EEG recordings obtained by a standard electrode array in patients with lateralised (10 Right, 9 Left-BECTS) or bilateral spikes (10 MF-BECTS) and in 17 age-matched controls. We analysed EEG activity using partial directed coherence, an estimator of connectivity based on the multivariate autoregressive models and calculated in- and out-degrees, strength, clustering coefficient and betweenness centrality. Results: In comparison with the controls, the awake EEG recordings of the patients with lateralised BECTS showed a minimal increase in out-degrees on F4 and F3. The greater differences, found during sleep, included significant reductions in both in- and out-degrees and strength in all of the patient groups, but in T4 or T3 showing increased out-degrees and strength in Right and Left-BECTS. Betweenness centrality was significantly reduced on C3 and C4 in the patients with MF-BECTS. Conclusions: Our observations suggest that the main finding in BECTS patients is widely reduced local connectivity. Significance: The network changes in BECTS can be interpreted as a permissive condition occurring in a developmental window that predisposes to seizure generation during spindle-sleep.
| Original language | English |
|---|---|
| Pages (from-to) | 2372-2379 |
| Number of pages | 8 |
| Journal | Clinical Neurophysiology |
| Volume | 129 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - Nov 1 2018 |
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Keywords
- Benign childhood epilepsy
- Effective connectivity
- Partial directed coherence
ASJC Scopus subject areas
- Sensory Systems
- Neurology
- Clinical Neurology
- Physiology (medical)
Cite this
Network characteristics in benign epilepsy with centro-temporal spikes patients indicating defective connectivity during spindle sleep : A partial directed coherence study of EEG signals. / Varotto, Giulia; Franceschetti, Silvana; Caputo, Davide; Visani, Elisa; Canafoglia, Laura; Freri, Elena; Ragona, Francesca; Avanzini, Giuliano; Panzica, Ferruccio.
In: Clinical Neurophysiology, Vol. 129, No. 11, 01.11.2018, p. 2372-2379.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Network characteristics in benign epilepsy with centro-temporal spikes patients indicating defective connectivity during spindle sleep
T2 - A partial directed coherence study of EEG signals
AU - Varotto, Giulia
AU - Franceschetti, Silvana
AU - Caputo, Davide
AU - Visani, Elisa
AU - Canafoglia, Laura
AU - Freri, Elena
AU - Ragona, Francesca
AU - Avanzini, Giuliano
AU - Panzica, Ferruccio
PY - 2018/11/1
Y1 - 2018/11/1
N2 - Objective: To investigate the changes in EEG connectivity in children with the typical presentation of benign epilepsy with centro-temporal spikes (BECTS). Methods: We compared awake and spindle-sleep EEG recordings obtained by a standard electrode array in patients with lateralised (10 Right, 9 Left-BECTS) or bilateral spikes (10 MF-BECTS) and in 17 age-matched controls. We analysed EEG activity using partial directed coherence, an estimator of connectivity based on the multivariate autoregressive models and calculated in- and out-degrees, strength, clustering coefficient and betweenness centrality. Results: In comparison with the controls, the awake EEG recordings of the patients with lateralised BECTS showed a minimal increase in out-degrees on F4 and F3. The greater differences, found during sleep, included significant reductions in both in- and out-degrees and strength in all of the patient groups, but in T4 or T3 showing increased out-degrees and strength in Right and Left-BECTS. Betweenness centrality was significantly reduced on C3 and C4 in the patients with MF-BECTS. Conclusions: Our observations suggest that the main finding in BECTS patients is widely reduced local connectivity. Significance: The network changes in BECTS can be interpreted as a permissive condition occurring in a developmental window that predisposes to seizure generation during spindle-sleep.
AB - Objective: To investigate the changes in EEG connectivity in children with the typical presentation of benign epilepsy with centro-temporal spikes (BECTS). Methods: We compared awake and spindle-sleep EEG recordings obtained by a standard electrode array in patients with lateralised (10 Right, 9 Left-BECTS) or bilateral spikes (10 MF-BECTS) and in 17 age-matched controls. We analysed EEG activity using partial directed coherence, an estimator of connectivity based on the multivariate autoregressive models and calculated in- and out-degrees, strength, clustering coefficient and betweenness centrality. Results: In comparison with the controls, the awake EEG recordings of the patients with lateralised BECTS showed a minimal increase in out-degrees on F4 and F3. The greater differences, found during sleep, included significant reductions in both in- and out-degrees and strength in all of the patient groups, but in T4 or T3 showing increased out-degrees and strength in Right and Left-BECTS. Betweenness centrality was significantly reduced on C3 and C4 in the patients with MF-BECTS. Conclusions: Our observations suggest that the main finding in BECTS patients is widely reduced local connectivity. Significance: The network changes in BECTS can be interpreted as a permissive condition occurring in a developmental window that predisposes to seizure generation during spindle-sleep.
KW - Benign childhood epilepsy
KW - Effective connectivity
KW - Partial directed coherence
UR - http://www.scopus.com/inward/record.url?scp=85053817602&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85053817602&partnerID=8YFLogxK
U2 - 10.1016/j.clinph.2018.09.008
DO - 10.1016/j.clinph.2018.09.008
M3 - Article
C2 - 30268930
AN - SCOPUS:85053817602
VL - 129
SP - 2372
EP - 2379
JO - Clinical Neurophysiology
JF - Clinical Neurophysiology
SN - 1388-2457
IS - 11
ER -