Neural 17β-estradiol facilitates long-term potentiation in the hippocampal CA1 region

S. Grassi, A. Tozzi, C. Costa, M. Tantucci, E. Colcelli, M. Scarduzio, P. Calabresi, V. E. Pettorossi

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

In the hippocampal formation many neuromodulators are possibly implied in the synaptic plasticity such as the long-term potentiation (LTP) induced by high-frequency stimulation (HFS) of afferent fibers. We investigated the involvement of locally synthesized neural 17β-estradiol (nE 2) in the induction of HFS-LTP in hippocampal slices from male rats by stimulating the Schaffer collateral fibers and recording the evoked field excitatory postsynaptic potential (fEPSP) in the CA1 region. We demonstrated that either the blockade of nE 2 synthesis by the aromatase inhibitor letrozole, or the antagonism of E 2 receptors (ERs) by ICI 182,780 did not prevent the induction of HFS-LTP, but reduced its amplitude by ~60%, without influencing its maintenance. Moreover, letrozole and ICI 182,780 did not affect the first short-term post-tetanic component of LTP and the paired-pulse facilitation (PPF). These findings demonstrate that nE 2 plays an important role in the induction phase of HFS-dependent LTP. Since the basal responses were not affected by the blocking agents, we suggest that the synthesis of nE 2 is induced or enhanced by HFS through aromatase activation. In this context, the local production of nE 2 seems to be a very effective mechanism to modulate the amplitude of LTP.

Original languageEnglish
Pages (from-to)67-73
Number of pages7
JournalNeuroscience
Volume192
DOIs
Publication statusPublished - Sep 29 2011

Fingerprint

Hippocampal CA1 Region
Long-Term Potentiation
Estradiol
letrozole
Hippocampus
Aromatase Inhibitors
Neuronal Plasticity
Aromatase
Excitatory Postsynaptic Potentials
Neurotransmitter Agents
Maintenance

Keywords

  • Aromatase
  • Estrogen receptors
  • Hippocampus CA1
  • LTP
  • Neurosteroids

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Grassi, S., Tozzi, A., Costa, C., Tantucci, M., Colcelli, E., Scarduzio, M., ... Pettorossi, V. E. (2011). Neural 17β-estradiol facilitates long-term potentiation in the hippocampal CA1 region. Neuroscience, 192, 67-73. https://doi.org/10.1016/j.neuroscience.2011.06.078

Neural 17β-estradiol facilitates long-term potentiation in the hippocampal CA1 region. / Grassi, S.; Tozzi, A.; Costa, C.; Tantucci, M.; Colcelli, E.; Scarduzio, M.; Calabresi, P.; Pettorossi, V. E.

In: Neuroscience, Vol. 192, 29.09.2011, p. 67-73.

Research output: Contribution to journalArticle

Grassi, S, Tozzi, A, Costa, C, Tantucci, M, Colcelli, E, Scarduzio, M, Calabresi, P & Pettorossi, VE 2011, 'Neural 17β-estradiol facilitates long-term potentiation in the hippocampal CA1 region', Neuroscience, vol. 192, pp. 67-73. https://doi.org/10.1016/j.neuroscience.2011.06.078
Grassi, S. ; Tozzi, A. ; Costa, C. ; Tantucci, M. ; Colcelli, E. ; Scarduzio, M. ; Calabresi, P. ; Pettorossi, V. E. / Neural 17β-estradiol facilitates long-term potentiation in the hippocampal CA1 region. In: Neuroscience. 2011 ; Vol. 192. pp. 67-73.
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