Neural and genetic correlates of antidepressant response to sleep deprivation: A functional magnetic resonance imaging study of moral valence decision in bipolar depression

Francesco Benedetti, Alessandro Bernasconi, Valeria Blasi, Marcello Cadioli, Cristina Colombo, Andrea Falini, Cristina Lorenzi, Daniele Radaelli, Giuseppe Scotti, Enrico Smeraldi

Research output: Contribution to journalArticle

Abstract

Context: Total sleep deprivation combined with light therapy causes rapid amelioration of bipolar depression. A polymorphism in the promoter for the serotonin transporter influences both antidepressant response and the structure and function of specific brain areas. Objective: To determine whether antidepressant therapy or the genotype of the serotonin transporter influence the pattern of neural response to a task targeting the depressive biases in information processing (moral valence decision). Design: Before-and-after trial studying the biologic correlates of response to treatment. Setting: University hospital. Patients: Twenty inpatients with bipolar depression. Intervention: Repeated total sleep deprivation combined with light therapy for 1 week. Main Outcome Measures: Brain blood oxygen level-dependent functional magnetic resonance imaging using a 3.0-T scanner before and after treatment. Self-ratings and observer ratings of mood (visual analog scale 3 times daily and Hamilton Depression Rating Scale) before and after treatment. Results: We found significant interactions of treatment (before and after), response to treatment (Hamilton Depression Rating Scale score

Original languageEnglish
Pages (from-to)179-187
Number of pages9
JournalArchives of General Psychiatry
Volume64
Issue number2
DOIs
Publication statusPublished - Feb 2007

ASJC Scopus subject areas

  • Psychiatry and Mental health

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