Neural and non-neural mechanisms influencing circulation during sleep

Giorgio Baccelli, Maurizio Guazzi, Giuseppe Mancia, Alberto Zanchetti

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Abstract

IN the past few years there has been increasing interest in cardiovascular changes during sleep, on the assumption that they might provide some insight into the neural control of circulation in a natural condition. The hypothesis that all cardiovascular events that occur during sleep are neurally mediated has never been crucially proved, however. Furthermore, sleep is accompanied by various haemodynamic phenomena which may well have different mechanisms. In the cat the greatest cardiovascular changes occur during desynchronized sleep (DS)1,2, a stage of sleep characterized by a desynchronized electroencephalogram and bursts of rapid eye movements, and in man associated with dreaming. We have shown recently that the arterial hypotension occurring during DS is dependent chiefly on a decreased peripheral resistance, change in cardiac output being small3. This is particularly true for animals subjected to sino-aortic deafferentation3, whose hypotension during DS is greatly exaggerated because of the removal of a buffer action exerted by arterial chemoceptors4. But in the few DS episodes during which hypotension is so profound as to cause electroencephalographic signs of cerebral anoxia (a phenomenon observed in deafferented animals only), the very large decrease in arterial pressure seems to be exclusively a consequence of a dramatic fall in cardiac output3. It has been suggested3, though not demonstrated, that the decrease in peripheral resistance might result from a reduction of sympathetic vasoconstrictor activity. The decrease in cardiac output, which is independent of cardiac innervation3,5, may also be a consequence of a reduction of sympathetic activity resulting in a dilatation of capacitance vessels and a decreased venous return, although non-neural mechanisms may well be involved.

Original languageEnglish
Pages (from-to)184-185
Number of pages2
JournalNature
Volume223
Issue number5202
DOIs
Publication statusPublished - 1969

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Baccelli, G., Guazzi, M., Mancia, G., & Zanchetti, A. (1969). Neural and non-neural mechanisms influencing circulation during sleep. Nature, 223(5202), 184-185. https://doi.org/10.1038/223184a0