Neural compensation in presymptomatic hAPP mouse models of Alzheimer's disease

Martine Ammassari-Teule

doi:10.1101/lm.050401.119

Neural compensation in presymptomatic hAPP mouse models of Alzheimer's disease

Martine Ammassari-Teule

Research output: Contribution to journal › Review article › peer-review

Abstract

Largely inspired from clinical concepts like brain reserve, cognitive reserve, and neural compensation, here we review data showing how neural circuits reorganize in presymptomatic and early symptomatic hAPP mice to maintain memory intact. By informing on molecular alterations and compensatory adaptations which take place in the brain before mice show cognitive impairments, these data can help to identify ultra-early disease markers that could be targeted in a therapeutic perspective aimed at preventing rather than treating cognitive deterioration.

Original language	English
Pages (from-to)	390-394
Number of pages	5
Journal	Learning and Memory
Volume	27
Issue number	9
DOIs	https://doi.org/10.1101/lm.050401.119
Publication status	Published - Sep 2020

ASJC Scopus subject areas

Neuropsychology and Physiological Psychology
Cognitive Neuroscience
Cellular and Molecular Neuroscience

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