Neural compensation in presymptomatic hAPP mouse models of Alzheimer's disease

Martine Ammassari-Teule

Research output: Contribution to journalReview articlepeer-review


Largely inspired from clinical concepts like brain reserve, cognitive reserve, and neural compensation, here we review data showing how neural circuits reorganize in presymptomatic and early symptomatic hAPP mice to maintain memory intact. By informing on molecular alterations and compensatory adaptations which take place in the brain before mice show cognitive impairments, these data can help to identify ultra-early disease markers that could be targeted in a therapeutic perspective aimed at preventing rather than treating cognitive deterioration.

Original languageEnglish
Pages (from-to)390-394
Number of pages5
JournalLearning and Memory
Issue number9
Publication statusPublished - Sep 2020

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

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