Neural correlates of local contextual processing deficits in schizophrenic patients

Noa Fogelson, Michele Ribolsi, Miguel Fernandez-Del-Olmo, Ivo Alex Rubino, Domenico Romeo, Giacomo Koch, Avi Peled

Research output: Contribution to journalArticle

Abstract

Deficits in processing contextual information are one of the main features of cognitive dysfunction in schizophrenia, but the neurophysiologic substrate underlying this dysfunction is poorly understood. We used ERPs to investigate local contextual processing in schizophrenic patients. Local context was defined as the occurrence of a short predictive series of stimuli occurring before delivery of a target event. Response times of predicted targets were faster in controls compared to patients. Schizophrenia patients failed to generate the P3b latency shift between predicted and random targets that was observed in controls and demonstrated a prominent reduction of the peak of an early latency context dependent positivity. The current study provides evidence of contextual processing deficits in schizophrenia patients by demonstrating alteration in the behavioral and neural correlates of local contextual processing.

Original languageEnglish
Pages (from-to)1217-1226
Number of pages10
JournalPsychophysiology
Volume48
Issue number9
DOIs
Publication statusPublished - Sep 2011

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Schizophrenia
Automatic Data Processing
Reaction Time
Cognitive Dysfunction

Keywords

  • Context
  • EEG
  • Neural correlate
  • P3b
  • Schizophrenia

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)
  • Experimental and Cognitive Psychology
  • Neuropsychology and Physiological Psychology

Cite this

Fogelson, N., Ribolsi, M., Fernandez-Del-Olmo, M., Rubino, I. A., Romeo, D., Koch, G., & Peled, A. (2011). Neural correlates of local contextual processing deficits in schizophrenic patients. Psychophysiology, 48(9), 1217-1226. https://doi.org/10.1111/j.1469-8986.2011.01195.x

Neural correlates of local contextual processing deficits in schizophrenic patients. / Fogelson, Noa; Ribolsi, Michele; Fernandez-Del-Olmo, Miguel; Rubino, Ivo Alex; Romeo, Domenico; Koch, Giacomo; Peled, Avi.

In: Psychophysiology, Vol. 48, No. 9, 09.2011, p. 1217-1226.

Research output: Contribution to journalArticle

Fogelson, N, Ribolsi, M, Fernandez-Del-Olmo, M, Rubino, IA, Romeo, D, Koch, G & Peled, A 2011, 'Neural correlates of local contextual processing deficits in schizophrenic patients', Psychophysiology, vol. 48, no. 9, pp. 1217-1226. https://doi.org/10.1111/j.1469-8986.2011.01195.x
Fogelson, Noa ; Ribolsi, Michele ; Fernandez-Del-Olmo, Miguel ; Rubino, Ivo Alex ; Romeo, Domenico ; Koch, Giacomo ; Peled, Avi. / Neural correlates of local contextual processing deficits in schizophrenic patients. In: Psychophysiology. 2011 ; Vol. 48, No. 9. pp. 1217-1226.
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