Neural correlates of naming errors across different neurodegenerative diseases: An FDG-PET study

E. Catricalà, C. Polito, L. Presotto, V. Esposito, A. Sala, F. Conca, C. Gasparri, V. Berti, M. Filippi, A. Pupi, S. Sorbi, S. Iannaccone, G. Magnani, S.F. Cappa, D. Perani

Research output: Contribution to journalArticlepeer-review

Abstract

OBJECTIVE: To investigate the types of errors produced in a picture naming task by patients with neurodegenerative dementia due to different etiologies and their neural correlates. METHODS: The same standardized picture naming test was administered to a consecutive sample of patients (n = 148) who had been studied with [18F] FDG-PET. The errors were analyzed in 3 categories (visual, semantic, and phonologic). The PET data were analyzed using an optimized single-subject procedure, and the statistical parametric mapping multiple regression design was used to explore the correlation between each type of error and brain hypometabolism in the whole group. Metabolic connectivity analyses were run at the group level on 7 left hemisphere cortical areas corresponding to an a priori defined naming network. RESULTS: Semantic errors were predominant in most patients, independent of clinical diagnosis. In the whole group analysis, visual errors correlated with hypometabolism in the right inferior occipital lobe and in the left middle occipital lobe. Semantic errors correlated with hypometabolism in the left fusiform gyrus, the inferior and middle temporal gyri, and the temporal pole. Phonologic errors were associated with hypometabolism in the left superior and middle temporal gyri. Both positive (occipital-posterior fusiform) and negative (anterior fusiform gyrus and the superior anterior temporal lobe) connectivity changes were associated with semantic errors. CONCLUSIONS: Naming errors reflect the dysfunction of separate stages of the naming process and are specific markers for different patterns of brain involvement. These correlations are not limited to primary progressive aphasia but extend to other neurodegenerative dementias. © 2020 American Academy of Neurology.
Original languageEnglish
Pages (from-to)e2816-e2830
JournalNeurology
Volume95
Issue number20
DOIs
Publication statusPublished - 2020

Keywords

  • fluorodeoxyglucose f 18
  • aged
  • Alzheimer disease
  • connectome
  • degenerative disease
  • dementia
  • diagnostic imaging
  • female
  • frontotemporal dementia
  • human
  • language
  • male
  • metabolism
  • occipital lobe
  • pathophysiology
  • pattern recognition
  • physiology
  • positron emission tomography
  • primary progressive aphasia
  • progressive supranuclear palsy
  • retrospective study
  • semantics
  • speech
  • temporal lobe
  • very elderly
  • Aged
  • Aged, 80 and over
  • Alzheimer Disease
  • Aphasia, Primary Progressive
  • Connectome
  • Dementia
  • Female
  • Fluorodeoxyglucose F18
  • Frontotemporal Dementia
  • Humans
  • Language
  • Male
  • Neurodegenerative Diseases
  • Occipital Lobe
  • Pattern Recognition, Visual
  • Positron-Emission Tomography
  • Retrospective Studies
  • Semantics
  • Speech
  • Supranuclear Palsy, Progressive
  • Temporal Lobe

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