Neural repetition suppression in ventral occipito-temporal cortex occurs during conscious and unconscious processing of frequent stimuli

Juan R. Vidal, Marcela Perrone-Bertolotti, Jonathan Levy, Luca De Palma, Lorella Minotti, Philippe Kahane, Olivier Bertrand, Antoine Lutz, Karim Jerbi, Jean Philippe Lachaux

Research output: Contribution to journalArticle

Abstract

Stimulus repetition can produce neural response attenuation in stimulus-category selective networks within the occipito-temporal lobe. It is hypothesized that this neural suppression reflects the functional sharpening of local neuronal assemblies which boosts information processing efficiency. This neural suppression phenomenon has been mainly reported during conditions of conscious stimulus perception. The question remains whether frequent stimuli processed in the absence of conscious perception also induce repetition suppression in those specialized networks. Using rare intracranial EEG recordings in the ventral occipito-temporal cortex (VOTC) of human epileptic patients we investigated neural repetition suppression in conditions of conscious and unconscious visual processing of words. To this end, we used an orthogonal design manipulating respectively stimulus repetition (frequent vs. unique stimuli) and conscious perception (masked vs. unmasked stimuli). By measuring the temporal dynamics of high-frequency broadband gamma activity in VOTC and testing for main and interaction effects, we report that early processing of words in word-form selective networks exhibits a temporal cascade of modulations by stimulus repetition and masking: neuronal attenuation initially is observed in response to repeated words (irrespective of consciousness), that is followed by a second modulation contingent upon word reportability (irrespective of stimulus repetition). Later on (>. 300. ms post-stimulus), a significant effect of conscious perception on the extent of repetition suppression was observed. The temporal dynamics of consciousness, the recognition memory processes and their interaction revealed in this study advance our understanding of their contributions to the neural mechanisms of word processing in VOTC.

Original languageEnglish
Pages (from-to)129-135
Number of pages7
JournalNeuroImage
Volume95
DOIs
Publication statusPublished - 2014

Keywords

  • Consciousness
  • Gamma-band
  • HFA
  • Intracranial EEG
  • Repetition suppression
  • Ventral occipito-temporal cortex
  • Visual masking

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Neurology
  • Medicine(all)

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    Vidal, J. R., Perrone-Bertolotti, M., Levy, J., De Palma, L., Minotti, L., Kahane, P., Bertrand, O., Lutz, A., Jerbi, K., & Lachaux, J. P. (2014). Neural repetition suppression in ventral occipito-temporal cortex occurs during conscious and unconscious processing of frequent stimuli. NeuroImage, 95, 129-135. https://doi.org/10.1016/j.neuroimage.2014.03.049