Neural stem/precursor cells for the treatment of ischemic stroke

Marco Bacigaluppi, Stefano Pluchino, Gianvito Martino, Ertugrul Kilic, Dirk M. Hermann

Research output: Contribution to journalArticlepeer-review

Abstract

In ischemic stroke, the third most frequent cause of mortality in industrialized countries, therapeutic options have until now been limited to the first hours after disease onset. Cell transplantation has emerged in various neurological disorders, including experimental stroke, as a successful recovery-promoting approach also in the post-acute stroke phase. However, before envisaging any translation into humans of such promising cell-based approaches we still need to clarify: (i) the ideal cell source for transplantation, (ii) the most appropriate route of cell administration, and, last but not least, (iii) the best approach to achieve an appropriate and functional integration of transplanted cells into the host tissue. Here we discuss, with special emphasis on neural stem/precursor cells, potential mechanisms that may be involved in the action of cell-based therapies in stroke.

Original languageEnglish
Pages (from-to)73-77
Number of pages5
JournalJournal of the Neurological Sciences
Volume265
Issue number1-2
DOIs
Publication statusPublished - Feb 15 2008

Keywords

  • Cell therapy
  • Focal cerebral ischemia
  • Stem cell

ASJC Scopus subject areas

  • Ageing
  • Clinical Neurology
  • Surgery
  • Neuroscience(all)
  • Developmental Neuroscience
  • Neurology

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