Neural substrates of internally-based and externally-cued timing: An activation likelihood estimation (ALE) meta-analysis of fMRI studies

Alice Teghil, Maddalena Boccia, Fabrizia D'Antonio, Antonella Di Vita, Carlo de Lena, Cecilia Guariglia

Research output: Contribution to journalReview article

Abstract

A dynamic interplay exists between Internally-Based (IBT) and Externally-Cued (ECT) time processing. While IBT processes support the self-generation of context-independent temporal representations, ECT mechanisms allow constructing temporal representations primarily derived from the structure of the sensory environment. We performed an activation likelihood estimation (ALE) meta-analysis on 177 fMRI experiments, from 79 articles, to identify brain areas involved in timing; two individual ALEs tested the hypothesis of a neural segregation between IBT and ECT. The general ALE highlighted a network involving supplementary motor area (SMA), intraparietal sulcus, inferior frontal gyrus (IFG), insula (INS) and basal ganglia. We found evidence of a partial dissociation between IBT and ECT. IBT relies on a subset of areas also involved in ECT, however ECT tasks activate SMA, right IFG, left precentral gyrus and INS in a significantly stronger way. Present results suggest that ECT involves the detection of environmental temporal regularities and their integration with the output of the IBT processing, to generate a representation of time which reflects the temporal metric of the environment.

Original languageEnglish
Pages (from-to)197-209
Number of pages13
JournalNeuroscience and Biobehavioral Reviews
Volume96
DOIs
Publication statusE-pub ahead of print - 2018

Keywords

  • ALE
  • Duration
  • fMRI
  • Meta-analysis
  • Rhythm
  • Time perception
  • Timing

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience

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