Neurite Orientation Dispersion and Density Imaging Color Maps to Characterize Brain Diffusion in Neurologic Disorders

E. Caverzasi, N. Papinutto, Antonella Castellano, Alyssa H. Zhu, Paola Scifo, Marco Riva, Lorenzo Bello, Andrea Falini, Aditya Bharatha, R. G. Henry

Research output: Contribution to journalArticle

Abstract

PURPOSE: Neurite orientation dispersion and density imaging (NODDI) has recently been developed to overcome diffusion technique limitations in modeling biological systems. This manuscript reports a preliminary investigation into the use of a single color-coded map to represent NODDI-derived information. MATERIALS AND METHODS: An optimized diffusion-weighted imaging protocol was acquired in several clinical neurological contexts including demyelinating disease, neoplastic process, stroke, and toxic/metabolic disease. The NODDI model was fitted to the diffusion datasets. NODDI is based on a three-compartment diffusion model and provides maps that quantify the contributions to the total diffusion signal in each voxel. The NODDI compartment maps were combined into a single 4-dimensional volume visualized as RGB image (red for anisotropic Gaussian diffusion, green for non-Gaussian anisotropic diffusion, and blue for isotropic Gaussian diffusion), in which the relative contributions of the different microstructural compartments can be easily appreciated. RESULTS: The NODDI color maps better describe the heterogeneity of neoplastic as well inflammatory lesions by identifying different tissue components within areas apparently homogeneous on conventional imaging. Moreover, NODDI color maps seem to be useful for identifying vasogenic edema differently from tumor-infiltrated edema. In multiple sclerosis, the NODDI color maps enable a visual assessment of the underlying microstructural changes, possibly highlighting an increased inflammatory component, within lesions and potentially in normal-appearing white matter. CONCLUSION: The NODDI color maps could make this technique valuable in a clinical setting, providing comprehensive and accessible information in normal and pathological brain tissues in different neurological pathologies.

Original languageEnglish
Pages (from-to)494-498
Number of pages5
JournalJournal of Neuroimaging
Volume26
Issue number5
DOIs
Publication statusPublished - Sep 1 2016

Fingerprint

Neurites
Nervous System Diseases
Color
Brain
Edema
Neoplastic Processes
Poisons
Metabolic Diseases
Demyelinating Diseases
Multiple Sclerosis
Stroke
Pathology

Keywords

  • color map
  • diffusion
  • glioma
  • neurite
  • NODDI

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology

Cite this

Caverzasi, E., Papinutto, N., Castellano, A., Zhu, A. H., Scifo, P., Riva, M., ... Henry, R. G. (2016). Neurite Orientation Dispersion and Density Imaging Color Maps to Characterize Brain Diffusion in Neurologic Disorders. Journal of Neuroimaging, 26(5), 494-498. https://doi.org/10.1111/jon.12359

Neurite Orientation Dispersion and Density Imaging Color Maps to Characterize Brain Diffusion in Neurologic Disorders. / Caverzasi, E.; Papinutto, N.; Castellano, Antonella; Zhu, Alyssa H.; Scifo, Paola; Riva, Marco; Bello, Lorenzo; Falini, Andrea; Bharatha, Aditya; Henry, R. G.

In: Journal of Neuroimaging, Vol. 26, No. 5, 01.09.2016, p. 494-498.

Research output: Contribution to journalArticle

Caverzasi, E, Papinutto, N, Castellano, A, Zhu, AH, Scifo, P, Riva, M, Bello, L, Falini, A, Bharatha, A & Henry, RG 2016, 'Neurite Orientation Dispersion and Density Imaging Color Maps to Characterize Brain Diffusion in Neurologic Disorders', Journal of Neuroimaging, vol. 26, no. 5, pp. 494-498. https://doi.org/10.1111/jon.12359
Caverzasi, E. ; Papinutto, N. ; Castellano, Antonella ; Zhu, Alyssa H. ; Scifo, Paola ; Riva, Marco ; Bello, Lorenzo ; Falini, Andrea ; Bharatha, Aditya ; Henry, R. G. / Neurite Orientation Dispersion and Density Imaging Color Maps to Characterize Brain Diffusion in Neurologic Disorders. In: Journal of Neuroimaging. 2016 ; Vol. 26, No. 5. pp. 494-498.
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