Neuro-hormonal effects of physical activity in the elderly

Grazia D. Femminella, Claudio de Lucia, Paola Iacotucci, Roberto Formisano, Laura Petraglia, Elena Allocca, Enza Ratto, Loreta D'Amico, Carlo Rengo, Gennaro Pagano, Domenico Bonaduce, Giuseppe Rengo, Nicola Ferrara

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Thanks to diagnostic and therapeutic advances, the elderly population is continuously increasing in the western countries. Accordingly, the prevalence of most chronic age-related diseases will increase considerably in the next decades, thus it will be necessary to implement effective preventive measures to face this epidemiological challenge. Among those, physical activity exerts a crucial role, since it has been proven to reduce the risk of cardiovascular diseases, diabetes, obesity, cognitive impairment and cancer. The favorable effects of exercise on cardiovascular homeostasis can be at least in part ascribed to the modulation of the neuro-hormonal systems implicated in cardiovascular pathophysiology. In the elderly, exercise has been shown to affect catecholamine secretion and biosynthesis, to positively modulate the renin-angiotensin-aldosterone system and to reduce the levels of plasma brain natriuretic peptides. Moreover, drugs modulating the neuro-hormonal systems may favorably affect physical capacity in the elderly. Thus, efforts should be made to actually make physical activity become part of the therapeutic tools in the elderly.

Original languageEnglish
Article numberArticle 378
JournalFrontiers in Physiology
Volume4 DEC
DOIs
Publication statusPublished - 2013

Fingerprint

Exercise
Brain Natriuretic Peptide
Renin-Angiotensin System
Catecholamines
Homeostasis
Cardiovascular Diseases
Obesity
Therapeutics
Pharmaceutical Preparations
Population
Neoplasms
Cognitive Dysfunction

Keywords

  • Brain natriuretic peptide
  • Elderly
  • Physical activity
  • Renin-angiotensin-aldosterone system
  • Sympathetic nervous system

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Femminella, G. D., de Lucia, C., Iacotucci, P., Formisano, R., Petraglia, L., Allocca, E., ... Ferrara, N. (2013). Neuro-hormonal effects of physical activity in the elderly. Frontiers in Physiology, 4 DEC, [Article 378]. https://doi.org/10.3389/fphys.2013.00378

Neuro-hormonal effects of physical activity in the elderly. / Femminella, Grazia D.; de Lucia, Claudio; Iacotucci, Paola; Formisano, Roberto; Petraglia, Laura; Allocca, Elena; Ratto, Enza; D'Amico, Loreta; Rengo, Carlo; Pagano, Gennaro; Bonaduce, Domenico; Rengo, Giuseppe; Ferrara, Nicola.

In: Frontiers in Physiology, Vol. 4 DEC, Article 378, 2013.

Research output: Contribution to journalArticle

Femminella, GD, de Lucia, C, Iacotucci, P, Formisano, R, Petraglia, L, Allocca, E, Ratto, E, D'Amico, L, Rengo, C, Pagano, G, Bonaduce, D, Rengo, G & Ferrara, N 2013, 'Neuro-hormonal effects of physical activity in the elderly', Frontiers in Physiology, vol. 4 DEC, Article 378. https://doi.org/10.3389/fphys.2013.00378
Femminella GD, de Lucia C, Iacotucci P, Formisano R, Petraglia L, Allocca E et al. Neuro-hormonal effects of physical activity in the elderly. Frontiers in Physiology. 2013;4 DEC. Article 378. https://doi.org/10.3389/fphys.2013.00378
Femminella, Grazia D. ; de Lucia, Claudio ; Iacotucci, Paola ; Formisano, Roberto ; Petraglia, Laura ; Allocca, Elena ; Ratto, Enza ; D'Amico, Loreta ; Rengo, Carlo ; Pagano, Gennaro ; Bonaduce, Domenico ; Rengo, Giuseppe ; Ferrara, Nicola. / Neuro-hormonal effects of physical activity in the elderly. In: Frontiers in Physiology. 2013 ; Vol. 4 DEC.
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