TY - JOUR
T1 - Neuro-Immune Cross-Talk in the Striatum
T2 - From Basal Ganglia Physiology to Circuit Dysfunction
AU - Mancini, Andrea
AU - Ghiglieri, Veronica
AU - Parnetti, Lucilla
AU - Calabresi, Paolo
AU - Di Filippo, Massimiliano
N1 - Funding Information:
This work has been supported by the Marlene and Paolo Fresco Institute for Parkinson’s and Movement Disorder, Fresco Parkinson Institute, New York University School of Medicine.
Publisher Copyright:
© Copyright © 2021 Mancini, Ghiglieri, Parnetti, Calabresi and Di Filippo.
PY - 2021/4/19
Y1 - 2021/4/19
N2 - The basal ganglia network is represented by an interconnected group of subcortical nuclei traditionally thought to play a crucial role in motor learning and movement execution. During the last decades, knowledge about basal ganglia physiology significantly evolved and this network is now considered as a key regulator of important cognitive and emotional processes. Accordingly, the disruption of basal ganglia network dynamics represents a crucial pathogenic factor in many neurological and psychiatric disorders. The striatum is the input station of the circuit. Thanks to the synaptic properties of striatal medium spiny neurons (MSNs) and their ability to express synaptic plasticity, the striatum exerts a fundamental integrative and filtering role in the basal ganglia network, influencing the functional output of the whole circuit. Although it is currently established that the immune system is able to regulate neuronal transmission and plasticity in specific cortical areas, the role played by immune molecules and immune/glial cells in the modulation of intra-striatal connections and basal ganglia activity still needs to be clarified. In this manuscript, we review the available evidence of immune-based regulation of synaptic activity in the striatum, also discussing how an abnormal immune activation in this region could be involved in the pathogenesis of inflammatory and degenerative central nervous system (CNS) diseases.
AB - The basal ganglia network is represented by an interconnected group of subcortical nuclei traditionally thought to play a crucial role in motor learning and movement execution. During the last decades, knowledge about basal ganglia physiology significantly evolved and this network is now considered as a key regulator of important cognitive and emotional processes. Accordingly, the disruption of basal ganglia network dynamics represents a crucial pathogenic factor in many neurological and psychiatric disorders. The striatum is the input station of the circuit. Thanks to the synaptic properties of striatal medium spiny neurons (MSNs) and their ability to express synaptic plasticity, the striatum exerts a fundamental integrative and filtering role in the basal ganglia network, influencing the functional output of the whole circuit. Although it is currently established that the immune system is able to regulate neuronal transmission and plasticity in specific cortical areas, the role played by immune molecules and immune/glial cells in the modulation of intra-striatal connections and basal ganglia activity still needs to be clarified. In this manuscript, we review the available evidence of immune-based regulation of synaptic activity in the striatum, also discussing how an abnormal immune activation in this region could be involved in the pathogenesis of inflammatory and degenerative central nervous system (CNS) diseases.
KW - basal ganglia
KW - immune system
KW - nucleus striatum
KW - synaptic plasticity
KW - synaptic transmission
UR - http://www.scopus.com/inward/record.url?scp=85105214091&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85105214091&partnerID=8YFLogxK
U2 - 10.3389/fimmu.2021.644294
DO - 10.3389/fimmu.2021.644294
M3 - Review article
C2 - 33953715
AN - SCOPUS:85105214091
VL - 12
JO - Frontiers in Immunology
JF - Frontiers in Immunology
SN - 1664-3224
M1 - 644294
ER -