Neuroactive steroids and diabetic complications in the nervous system

Silvia Giatti, R Mastrangelo, M D'Antonio, M Pesaresi, S Romano, S Diviccaro, D Caruso, N Mitro, RC Melcangi

Research output: Contribution to journalArticle

Abstract

Important complications of diabetes mellitus in the nervous system are represented by diabetic peripheral neuropathy and diabetic encephalopathy. In this context, an important link is represented by neuroactive steroids (i.e., steroids coming from peripheral glands and affecting nervous functionality as well as directly synthesized in the nervous system). Indeed, diabetes does not only affect the reproductive axis and consequently the levels of sex steroid hormones, but also those of neuroactive steroids. Indeed, as will be here summarized, the levels of these neuromodulators present in the central and peripheral nervous system are affected by the pathology in a sex-dimorphic way. In addition, some of these neuroactive steroids, such as the metabolites of progesterone or testosterone, as well as pharmacological tools able to increase their levels have been demonstrated, in experimental models, to be promising protective agents against diabetic peripheral neuropathy and diabetic encephalopathy. © 2017.
Original languageEnglish
Pages (from-to)58-69
Number of pages12
JournalFrontiers in Neuroendocrinology
Volume48
Issue number4
DOIs
Publication statusPublished - 2018

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Diabetes Complications
Nervous System
Steroids
Diabetic Neuropathies
Brain Diseases
Peripheral Nervous System Diseases
Protective Agents
Peripheral Nervous System
Gonadal Steroid Hormones
Progesterone
Neurotransmitter Agents
Testosterone
Theoretical Models
Central Nervous System
Pharmacology
Pathology

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Giatti, S., Mastrangelo, R., D'Antonio, M., Pesaresi, M., Romano, S., Diviccaro, S., ... Melcangi, RC. (2018). Neuroactive steroids and diabetic complications in the nervous system. Frontiers in Neuroendocrinology, 48(4), 58-69. https://doi.org/10.1016/j.yfrne.2017.07.006

Neuroactive steroids and diabetic complications in the nervous system. / Giatti, Silvia; Mastrangelo, R; D'Antonio, M; Pesaresi, M; Romano, S; Diviccaro, S; Caruso, D; Mitro, N; Melcangi, RC.

In: Frontiers in Neuroendocrinology, Vol. 48, No. 4, 2018, p. 58-69.

Research output: Contribution to journalArticle

Giatti, S, Mastrangelo, R, D'Antonio, M, Pesaresi, M, Romano, S, Diviccaro, S, Caruso, D, Mitro, N & Melcangi, RC 2018, 'Neuroactive steroids and diabetic complications in the nervous system', Frontiers in Neuroendocrinology, vol. 48, no. 4, pp. 58-69. https://doi.org/10.1016/j.yfrne.2017.07.006
Giatti, Silvia ; Mastrangelo, R ; D'Antonio, M ; Pesaresi, M ; Romano, S ; Diviccaro, S ; Caruso, D ; Mitro, N ; Melcangi, RC. / Neuroactive steroids and diabetic complications in the nervous system. In: Frontiers in Neuroendocrinology. 2018 ; Vol. 48, No. 4. pp. 58-69.
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