Neuroadrenergic disarray in pseudo-resistant and resistant hypertension

Guido Grassi, Michele Bombelli, Silvia Buzzi, Marco Volpe, Gianmaria Brambilla

Research output: Contribution to journalArticlepeer-review


Several studies have investigated the behavior of sympathetic cardiovascular drive in essential hypertension, providing conclusive evidence of the adrenergic activation characterizing this condition. These studies have also shown the importance of neuroadrenergic overdrive in the development and progression of the hypertensive state as well as in the pathogenesis of hypertension-related end-organ damage. The information available on the sympathetic nervous system's behavior in 'pseudo-resistant' and 'true resistant' hypertension is much more scarce. This paper will review the available knowledge on this issue by examining the data collected via indirect and direct approaches to investigate adrenergic function in resistant hypertension as well as the effects of pharmacological and non-pharmacological interventions.

Original languageEnglish
Pages (from-to)479-483
Number of pages5
JournalHypertension Research
Issue number6
Publication statusPublished - 2014


  • ambulatory blood pressure monitoring
  • office blood pressure
  • resistant hypertension
  • sympathetic nervous system
  • white-coat hypertension

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Medicine(all)


Dive into the research topics of 'Neuroadrenergic disarray in pseudo-resistant and resistant hypertension'. Together they form a unique fingerprint.

Cite this