Neuroanatomy of Alzheimer's Disease and Late-Life Depression: A Coordinate-Based Meta-Analysis of MRI Studies

Maddalena Boccia, Mauro Acierno, Laura Piccardi

Research output: Contribution to journalArticle


Depression and cognitive impairment are both common disorders in elderly people and frequently occur together. Due to the presence of a common set of behavioral and cognitive symptoms, differential diagnosis may become arduous. Neuroimaging may offer a good tool during diagnosis.We performed a coordinate-based meta-analysis to compare gray matter changes in Alzheimer's disease (AD) and late-life depression (LLD). AD and LLD led to brain atrophy in networks only partially overlapping. Both conditions are linked to a reduction of the bilateral hippocampal volume, but AD is correlated with great atrophy in the left anterior hippocampus and bilateral posterior cingulate cortex, while LLD is correlated with great atrophy in the precuneus, superior frontal gyrus, and ventromedial frontal cortex. Present results shed some light on neural underpinnings of AD and LLD and provide new useful evidence for differential diagnosis.

Original languageEnglish
Pages (from-to)963-970
Number of pages8
JournalJournal of Alzheimer's Disease
Issue number4
Publication statusPublished - Jun 26 2015



  • Aging
  • Alzheimer's disease
  • dementia
  • late-life depression
  • magnetic resonance imaging
  • neuroimaging
  • voxel-based morphometry

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology
  • Clinical Psychology

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