TY - JOUR
T1 - Neuroblastoma in patients over 12 years old
T2 - A 20-year experience at the Istituto Nazionale Tumori of Milan
AU - Podda, Marta Giorgia
AU - Luksch, Roberto
AU - Polastri, Daniela
AU - Gandola, Lorenza
AU - Piva, Luigi
AU - Collini, Paola
AU - Cefalo, Graziella
AU - Terenziani, Monica
AU - Ferrari, Andrea
AU - Casanova, Michela
AU - Spreafico, Filippo
AU - Meazza, Cristina
AU - Castellani, Maria Rita
AU - Catania, Serena
AU - Schiavello, Elisabetta
AU - Marchianò, Alfonso
AU - Massimino, Maura
PY - 2010/9
Y1 - 2010/9
N2 - Aims and background. Neuroblastoma is the most common solid extracranial tumor in children. The median age of onset is 2 years, with more than 95% of patients younger than 10 years at diagnosis. As neuroblastoma is rare in adolescents and exceedingly rare in adults, few series are reported in the literature. In the present study, we analyzed the outcomes and clinical characteristics of a mono-institutional series. Methods. We describe 27 consecutive patients over 12 years of age (range, 12-69) with previously untreated neuroblastoma treated at our Institution between 1982 and 2001. Results. Overall survival at 5 and 10 years was 40% and 20%, respectively, and progression-free survival at 5 and 10 years was 18%. In the present series, there was a long interval between the onset of signs/symptoms and diagnosis, and between recurrence/ progression and death. None had MYCN amplification. Conclusions. The passive course of the disease in most of our patients did not reflect a more favorable outcome compared with younger patients, thus suggesting a possible genetically different subset of neuroblastoma in older patients.
AB - Aims and background. Neuroblastoma is the most common solid extracranial tumor in children. The median age of onset is 2 years, with more than 95% of patients younger than 10 years at diagnosis. As neuroblastoma is rare in adolescents and exceedingly rare in adults, few series are reported in the literature. In the present study, we analyzed the outcomes and clinical characteristics of a mono-institutional series. Methods. We describe 27 consecutive patients over 12 years of age (range, 12-69) with previously untreated neuroblastoma treated at our Institution between 1982 and 2001. Results. Overall survival at 5 and 10 years was 40% and 20%, respectively, and progression-free survival at 5 and 10 years was 18%. In the present series, there was a long interval between the onset of signs/symptoms and diagnosis, and between recurrence/ progression and death. None had MYCN amplification. Conclusions. The passive course of the disease in most of our patients did not reflect a more favorable outcome compared with younger patients, thus suggesting a possible genetically different subset of neuroblastoma in older patients.
KW - Adolescents
KW - Adults
KW - Ganglioneuroblastoma
KW - Neuroblastoma
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M3 - Article
C2 - 21302612
AN - SCOPUS:78650483493
VL - 96
SP - 684
EP - 689
JO - Tumori
JF - Tumori
SN - 0300-8916
IS - 5
ER -