Neuroblastoma in the newborn. A study of the Italian Neuroblastoma Registry

Anna Rita Gigliotti, Andrea Di Cataldo, Stefania Sorrentino, Stefano Parodi, Antonino Rizzo, Piero Buffa, Claudio Granata, Angela Rita Sementa, Anna Maria Fagnani, Massimo Provenzi, Arcangelo Prete, Carmelita D'Ippolito, Anna Clerico, Aurora Castellano, Gian Paolo Tonini, Massimo Conte, Alberto Garaventa, Bruno De Bernardi

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Aim: Presenting features, treatment and outcome of 134 newborns with neuroblastoma diagnosed over a 27-year period are described. Methods: Analyses were performed on the entire cohort and on patients distributed over three periods of diagnosis. Results: Twenty-seven tumours (20.1%) were detected prenatally. Localised disease prevailed (65.7%) with an increase of stage 1 patients over time from 18.8% to 46.5%. Disseminated disease accounted for 34.3% of tumours with only one stage 4 and 45 stage 4S. Five-year overall survival (OS) of the entire cohort was 88.3%. Five/88 patients with localised disease died, including three who died of complications (OS, 95.3%). The only stage 4 patient survived. Eleven/45 stage 4S patients died, including 7/18 symptomatic and 4/27 asymptomatic (OS, 74.1%). Conclusion: The outcome of neuroblastoma in newborns is excellent. In localised tumours, surgery-related deaths outnumbered deaths due to disease. Symptomatic stage 4S patients were at greater risk of dying.

Original languageEnglish
Pages (from-to)3220-3227
Number of pages8
JournalEuropean Journal of Cancer
Volume45
Issue number18
DOIs
Publication statusPublished - Dec 2009

Fingerprint

Neuroblastoma
Registries
Newborn Infant
Survival
Neoplasms

Keywords

  • Infant
  • MYCN gene
  • Neuroblastoma
  • Newborn
  • Prenatal diagnosis
  • Stage 4S disease

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Gigliotti, A. R., Di Cataldo, A., Sorrentino, S., Parodi, S., Rizzo, A., Buffa, P., ... De Bernardi, B. (2009). Neuroblastoma in the newborn. A study of the Italian Neuroblastoma Registry. European Journal of Cancer, 45(18), 3220-3227. https://doi.org/10.1016/j.ejca.2009.08.020

Neuroblastoma in the newborn. A study of the Italian Neuroblastoma Registry. / Gigliotti, Anna Rita; Di Cataldo, Andrea; Sorrentino, Stefania; Parodi, Stefano; Rizzo, Antonino; Buffa, Piero; Granata, Claudio; Sementa, Angela Rita; Fagnani, Anna Maria; Provenzi, Massimo; Prete, Arcangelo; D'Ippolito, Carmelita; Clerico, Anna; Castellano, Aurora; Tonini, Gian Paolo; Conte, Massimo; Garaventa, Alberto; De Bernardi, Bruno.

In: European Journal of Cancer, Vol. 45, No. 18, 12.2009, p. 3220-3227.

Research output: Contribution to journalArticle

Gigliotti, AR, Di Cataldo, A, Sorrentino, S, Parodi, S, Rizzo, A, Buffa, P, Granata, C, Sementa, AR, Fagnani, AM, Provenzi, M, Prete, A, D'Ippolito, C, Clerico, A, Castellano, A, Tonini, GP, Conte, M, Garaventa, A & De Bernardi, B 2009, 'Neuroblastoma in the newborn. A study of the Italian Neuroblastoma Registry', European Journal of Cancer, vol. 45, no. 18, pp. 3220-3227. https://doi.org/10.1016/j.ejca.2009.08.020
Gigliotti AR, Di Cataldo A, Sorrentino S, Parodi S, Rizzo A, Buffa P et al. Neuroblastoma in the newborn. A study of the Italian Neuroblastoma Registry. European Journal of Cancer. 2009 Dec;45(18):3220-3227. https://doi.org/10.1016/j.ejca.2009.08.020
Gigliotti, Anna Rita ; Di Cataldo, Andrea ; Sorrentino, Stefania ; Parodi, Stefano ; Rizzo, Antonino ; Buffa, Piero ; Granata, Claudio ; Sementa, Angela Rita ; Fagnani, Anna Maria ; Provenzi, Massimo ; Prete, Arcangelo ; D'Ippolito, Carmelita ; Clerico, Anna ; Castellano, Aurora ; Tonini, Gian Paolo ; Conte, Massimo ; Garaventa, Alberto ; De Bernardi, Bruno. / Neuroblastoma in the newborn. A study of the Italian Neuroblastoma Registry. In: European Journal of Cancer. 2009 ; Vol. 45, No. 18. pp. 3220-3227.
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