Neurochemical and behavioural modifications induced by scrapie infection in golden hamsters

S. R. Bareggi, D. Braida, M. Gervasoni, G. Carcassola, C. Pollera, C. Vergerio, M. Sala

Research output: Contribution to journalArticlepeer-review

Abstract

Scrapie-infected hamsters were tested for spontaneous motor activity and passive avoidance at various times after infection. After testing, some animals were killed and their whole brains assayed for norepinephrine, dopamine, serotonin and their metabolites. The apparent rate of turnover was estimated in terms of metabolite/amine concentrations. After 70 days, there was a decrease in passive avoidance and dopamine and serotonin. Passive avoidance correlated with the apparent rate of turnover of dopamine, whereas motor activity correlated with that of serotonin and dopamine.

Original languageEnglish
Pages (from-to)237-241
Number of pages5
JournalBrain Research
Volume984
Issue number1-2
DOIs
Publication statusPublished - Sep 12 2003

Keywords

  • Brain monoamine
  • Motor activity
  • Neurodegenerative prion disease
  • Passive avoidance

ASJC Scopus subject areas

  • Neuroscience(all)

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