Neurochemical effects of buspirone in rat hippocampus: Evidence for selective activation of 5HT neurons

T. Mennini, M. Gobbi, F. Ponzio, S. Garattini

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29 Citations (Scopus)

Abstract

The effect of buspirone on neurotransmitter systems in rat hippocampus has been evaluated in vitro and in vivo. In vitro buspirone does not affect the specific binding of 3H-flunitrazepam, 3-GABA, 3H-dexetimide, but displaces 3H-5HT binding with nanomolar affinity. Oral administration of buspirone does not modify the hippocampal concentrations of GABA, acetylcholine, choline and of 3H-flunitrazepam specifically bound in vivo, but results in a dose-dependent reduction of 5HIAA and noradrenaline concentrations. While the effect on noradrenaline is also obtained in striatum of buspirone-treated animals, the effect on 5HIAA shows a regional specificity. The in vitro and in vivo data suggest that buspirone specifically activates 5HT neurons in hippocampus, and are compared with those obtained with diazepam.

Original languageEnglish
Pages (from-to)40-49
Number of pages10
JournalArchives Internationales de Pharmacodynamie et de Therapie
Volume279
Issue number1
Publication statusPublished - 1986

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Buspirone
Hippocampus
Neurons
Flunitrazepam
gamma-Aminobutyric Acid
Dexetimide
Norepinephrine
Diazepam
Choline
Acetylcholine
Neurotransmitter Agents
Oral Administration
In Vitro Techniques

ASJC Scopus subject areas

  • Pharmacology

Cite this

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abstract = "The effect of buspirone on neurotransmitter systems in rat hippocampus has been evaluated in vitro and in vivo. In vitro buspirone does not affect the specific binding of 3H-flunitrazepam, 3-GABA, 3H-dexetimide, but displaces 3H-5HT binding with nanomolar affinity. Oral administration of buspirone does not modify the hippocampal concentrations of GABA, acetylcholine, choline and of 3H-flunitrazepam specifically bound in vivo, but results in a dose-dependent reduction of 5HIAA and noradrenaline concentrations. While the effect on noradrenaline is also obtained in striatum of buspirone-treated animals, the effect on 5HIAA shows a regional specificity. The in vitro and in vivo data suggest that buspirone specifically activates 5HT neurons in hippocampus, and are compared with those obtained with diazepam.",
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AU - Mennini, T.

AU - Gobbi, M.

AU - Ponzio, F.

AU - Garattini, S.

PY - 1986

Y1 - 1986

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