Abstract
The effect of buspirone on neurotransmitter systems in rat hippocampus has been evaluated in vitro and in vivo. In vitro buspirone does not affect the specific binding of 3H-flunitrazepam, 3-GABA, 3H-dexetimide, but displaces 3H-5HT binding with nanomolar affinity. Oral administration of buspirone does not modify the hippocampal concentrations of GABA, acetylcholine, choline and of 3H-flunitrazepam specifically bound in vivo, but results in a dose-dependent reduction of 5HIAA and noradrenaline concentrations. While the effect on noradrenaline is also obtained in striatum of buspirone-treated animals, the effect on 5HIAA shows a regional specificity. The in vitro and in vivo data suggest that buspirone specifically activates 5HT neurons in hippocampus, and are compared with those obtained with diazepam.
| Original language | English |
|---|---|
| Pages (from-to) | 40-49 |
| Number of pages | 10 |
| Journal | Archives Internationales de Pharmacodynamie et de Therapie |
| Volume | 279 |
| Issue number | 1 |
| Publication status | Published - 1986 |
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ASJC Scopus subject areas
- Pharmacology
Cite this
Neurochemical effects of buspirone in rat hippocampus : Evidence for selective activation of 5HT neurons. / Mennini, T.; Gobbi, M.; Ponzio, F.; Garattini, S.
In: Archives Internationales de Pharmacodynamie et de Therapie, Vol. 279, No. 1, 1986, p. 40-49.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Neurochemical effects of buspirone in rat hippocampus
T2 - Evidence for selective activation of 5HT neurons
AU - Mennini, T.
AU - Gobbi, M.
AU - Ponzio, F.
AU - Garattini, S.
PY - 1986
Y1 - 1986
N2 - The effect of buspirone on neurotransmitter systems in rat hippocampus has been evaluated in vitro and in vivo. In vitro buspirone does not affect the specific binding of 3H-flunitrazepam, 3-GABA, 3H-dexetimide, but displaces 3H-5HT binding with nanomolar affinity. Oral administration of buspirone does not modify the hippocampal concentrations of GABA, acetylcholine, choline and of 3H-flunitrazepam specifically bound in vivo, but results in a dose-dependent reduction of 5HIAA and noradrenaline concentrations. While the effect on noradrenaline is also obtained in striatum of buspirone-treated animals, the effect on 5HIAA shows a regional specificity. The in vitro and in vivo data suggest that buspirone specifically activates 5HT neurons in hippocampus, and are compared with those obtained with diazepam.
AB - The effect of buspirone on neurotransmitter systems in rat hippocampus has been evaluated in vitro and in vivo. In vitro buspirone does not affect the specific binding of 3H-flunitrazepam, 3-GABA, 3H-dexetimide, but displaces 3H-5HT binding with nanomolar affinity. Oral administration of buspirone does not modify the hippocampal concentrations of GABA, acetylcholine, choline and of 3H-flunitrazepam specifically bound in vivo, but results in a dose-dependent reduction of 5HIAA and noradrenaline concentrations. While the effect on noradrenaline is also obtained in striatum of buspirone-treated animals, the effect on 5HIAA shows a regional specificity. The in vitro and in vivo data suggest that buspirone specifically activates 5HT neurons in hippocampus, and are compared with those obtained with diazepam.
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UR - http://www.scopus.com/inward/citedby.url?scp=0022628886&partnerID=8YFLogxK
M3 - Article
C2 - 2421657
AN - SCOPUS:0022628886
VL - 279
SP - 40
EP - 49
JO - Archives Internationales de Pharmacodynamie et de Therapie
JF - Archives Internationales de Pharmacodynamie et de Therapie
SN - 0003-9780
IS - 1
ER -