Neurodegenerative diseases: Clinical aspects, molecular genetics and biomarkers

Research output: Book/ReportBook

Abstract

This book gives an overview of the current knowledge on the most common neurodegenerative diseases, including Alzheimer’s disease, frontotemporal lobar degeneration, Lewy body dementia, Parkinson’s disease, amyotrophic lateral sclerosis, and additional less common neurodegenerative diseases. Both clinical and basic aspects of each disease are treated, including novel diagnostic criteria, old and new treatments, basic discoveries (genetics, epigenetics and molecular biology), and translation of basic research into biomarkers for early diagnosis, particularly to identify peripheral biomarkers. In addition, emerging data indicate that neurodegeneration seems to also be present in classically non-degenerative disorders. Therefore, a chapter about overlapping mechanisms between dementias and psychiatric disorders is included, as well as a description of the role of neurodegeneration in multiple sclerosis. Neurodegenerative Diseases is aimed at clinicians, particularly those working in academic hospitals. This multidisciplinary book will also be of interest to basic researchers in medical fields.

Original languageEnglish
PublisherSpringer International Publishing AG
Number of pages407
ISBN (Electronic)9783319729381
ISBN (Print)9783319729374
DOIs
Publication statusPublished - Jan 1 2018

Keywords

  • Alzheimer’s
  • Amyotrophic Lateral Sclerosis
  • Dementia neurodegeneration
  • Frontotemporal Lobar Degeneration

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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