Neurodevelopmental outcome in congenital diaphragmatic hernia survivors: Role of ventilatory time

Francesca Bevilacqua, Francesco Morini, Antonio Zaccara, Laura Valfrè, Irma Capolupo, Pietro Bagolan, Lucia Aite

Research output: Contribution to journalArticlepeer-review


Background Neurodevelopmental impairment is one of the most significant morbidities among CDH survivors. Purpose Assess correlation between ventilatory time (VT) and short-term neurodevelopmental outcome in congenital diaphragmatic hernia (CDH) survivors. Methods A prospective longitudinal study was conducted between 2008 and 2012. Assessment of mental and motor development was performed at 6 and 12 months by Bayley Scales of Infant and Toddler Development - 3rd Edition (BSID-III). ROC curve analysis was used. Results Forty-two subjects were included in the study. There was a significant inverse correlation between neurodevelopment at 6 and 12 months and VT during first admission (p <0.0001). VT predicting the risk of moderate (BSID-III <85) and severe (BSID-III <70) delay was 13 and 28 days, respectively (area under the curve - delay <85: 6 months mental 0.943 and motor 0.992; 12 months mental 0.877 and motor 0.925; delay <70: 6 months mental 0.934 and motor 0.943; 12 months mental 0.906 and motor 0.975; p <0.0001). Conclusions VT should be considered an important marker to identify subjects at risk for short-term neurodevelopmental delay in CDH survivors. Early follow-up intervention therapy should be activated in every baby with a history exceeding 13 days of VT.

Original languageEnglish
Pages (from-to)394-398
Number of pages5
JournalJournal of Pediatric Surgery
Issue number3
Publication statusPublished - Mar 1 2015

ASJC Scopus subject areas

  • Surgery
  • Pediatrics, Perinatology, and Child Health
  • Medicine(all)


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