Neurodevelopmental toxicity of methylmercury: Laboratory animal data and their contribution to human risk assessment

Anna F. Castoldi, Natalia Onishchenko, Carolina Johansson, Teresa Coccini, Elisa Roda, Marie Vahter, Sandra Ceccatelli, Luigi Manzo

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

Methylmercury (MeHg) is one of the most significant public health hazards. The clinical findings in the victims of the Japanese and Iraqi outbreaks have disclosed the pronounced susceptibility of the developing brain to MeHg poisoning. This notion has triggered worldwide scientific attention toward the long-term consequences of prenatal exposure on child development in communities with chronic low level dietary exposure. MeHg neurodevelopmental effects have been extensively investigated in laboratory animals under well-controlled exposure conditions. This article provides an updated overview of the main neuromorphological and neurobehavioral changes reported in non-human primates and rodents following developmental exposure to MeHg. Different aspects of MeHg's effects on the immature organism are reported, with particular reference to the delayed onset of symptoms and the persistency of central nervous system (CNS) injury/dysfunction. Particular attention is paid to the comparative toxicity assessment across species, and to the degree of concordance/discordance between human and animal data. The contribution of animal studies to define the role of potential effect modifiers and variables on MeHg dose-response relationships is also addressed. The ultimate goal is to discuss the relevance of laboratory animal results, as a complementary tool to human data, with regard to the human risk assessment process.

Original languageEnglish
Pages (from-to)215-229
Number of pages15
JournalRegulatory Toxicology and Pharmacology
Volume51
Issue number2
DOIs
Publication statusPublished - Jul 2008

Fingerprint

Laboratory Animals
Risk assessment
Toxicity
Animals
Nervous System Trauma
Child Development
Poisoning
Health hazards
Primates
Disease Outbreaks
Rodentia
Neurology
Public health
Central Nervous System
Public Health
Brain

Keywords

  • Behavior
  • Brain toxicity
  • Cognitive effects
  • Monkeys
  • Motor function
  • Neurodevelopment
  • Risk assessment
  • Rodents
  • Sensory function

ASJC Scopus subject areas

  • Toxicology

Cite this

Neurodevelopmental toxicity of methylmercury : Laboratory animal data and their contribution to human risk assessment. / Castoldi, Anna F.; Onishchenko, Natalia; Johansson, Carolina; Coccini, Teresa; Roda, Elisa; Vahter, Marie; Ceccatelli, Sandra; Manzo, Luigi.

In: Regulatory Toxicology and Pharmacology, Vol. 51, No. 2, 07.2008, p. 215-229.

Research output: Contribution to journalArticle

Castoldi, Anna F. ; Onishchenko, Natalia ; Johansson, Carolina ; Coccini, Teresa ; Roda, Elisa ; Vahter, Marie ; Ceccatelli, Sandra ; Manzo, Luigi. / Neurodevelopmental toxicity of methylmercury : Laboratory animal data and their contribution to human risk assessment. In: Regulatory Toxicology and Pharmacology. 2008 ; Vol. 51, No. 2. pp. 215-229.
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