TY - JOUR
T1 - Neuroendocrine and Metabolic Effects of Low-Calorie and Non-Calorie Sweeteners
AU - Moriconi, Eleonora
AU - Feraco, Alessandra
AU - Marzolla, Vincenzo
AU - Infante, Marco
AU - Lombardo, Mauro
AU - Fabbri, Andrea
AU - Caprio, Massimiliano
N1 - Funding Information:
We wish to thank Dr. Elisa Fabbrini for critical reading of the manuscript. Figures generation has been performed by using BioRender software. This work is dedicated to the shining memory of Dr. Italo Nosari, and to all other healthcare workers who died of COVID-19. Funding. This paper was funded, in part, by the Italian Ministry of Health (Ricerca Corrente), and by MIUR (Progetti di Ricerca di Interesse Nazionale 2017?Project code 2017ASTXC3?to MC, Work Package Leader).
Publisher Copyright:
© Copyright © 2020 Moriconi, Feraco, Marzolla, Infante, Lombardo, Fabbri and Caprio.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/7/16
Y1 - 2020/7/16
N2 - Since excessive sugar consumption has been related to the development of chronic metabolic diseases prevalent in the western world, the use of sweeteners has gradually increased worldwide over the last few years. Although low- and non-calorie sweeteners may represent a valuable tool to reduce calorie intake and prevent weight gain, studies investigating the safety and efficacy of these compounds in the short- and long-term period are scarce and controversial. Therefore, future studies will need to elucidate the potential beneficial and/or detrimental effects of different types of sweeteners on metabolic health (energy balance, appetite, body weight, cardiometabolic risk factors) in healthy subjects and patients with diabetes, obesity and metabolic syndrome. In this regard, the impact of different sweeteners on central nervous system, gut hormones and gut microbiota is important, given the strong implications that changes in such systems may have for human health. The aim of this narrative review is to summarize the current evidence for the neuroendocrine and metabolic effects of sweeteners, as well as their impact on gut microbiota. Finally, we briefly discuss the advantages of the use of sweeteners in the context of very-low calorie ketogenic diets.
AB - Since excessive sugar consumption has been related to the development of chronic metabolic diseases prevalent in the western world, the use of sweeteners has gradually increased worldwide over the last few years. Although low- and non-calorie sweeteners may represent a valuable tool to reduce calorie intake and prevent weight gain, studies investigating the safety and efficacy of these compounds in the short- and long-term period are scarce and controversial. Therefore, future studies will need to elucidate the potential beneficial and/or detrimental effects of different types of sweeteners on metabolic health (energy balance, appetite, body weight, cardiometabolic risk factors) in healthy subjects and patients with diabetes, obesity and metabolic syndrome. In this regard, the impact of different sweeteners on central nervous system, gut hormones and gut microbiota is important, given the strong implications that changes in such systems may have for human health. The aim of this narrative review is to summarize the current evidence for the neuroendocrine and metabolic effects of sweeteners, as well as their impact on gut microbiota. Finally, we briefly discuss the advantages of the use of sweeteners in the context of very-low calorie ketogenic diets.
KW - body weight
KW - diabetes
KW - metabolic health
KW - microbiota
KW - obesity
KW - safety
KW - sugar
KW - VLCKD
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U2 - 10.3389/fendo.2020.00444
DO - 10.3389/fendo.2020.00444
M3 - Review article
AN - SCOPUS:85088794955
VL - 11
JO - Frontiers in Endocrinology
JF - Frontiers in Endocrinology
SN - 1664-2392
M1 - 444
ER -