Neuroendocrine and psychopathological measures in anorexia nervosa: Resemblances to primary affective disorders

Francesca Brambilla, Franco Cavagnini, Cecilia Invitti, Franco Poterzio, Mario Lampertico, Laura Sali, Mauricio Maggioni, Carlo Candolfi, Alberto E. Panerai, Eugenio E. Müdler

Research output: Contribution to journalArticlepeer-review

Abstract

Clinical and biochemical data suggest a link between anorexia nervosa (AN) and primary affective disorders (PAD). In 14 female patients, aged 15-40 years, with 7-month to 11-year histories of AN, we studied circadian cortisol periodicity, response to the dexamethasone suppression test (DST), and plasma levels of β-endorphin and β-lipotropin before and after desimipramine therapy. Possible correlations were sought among neuroendocrine impairments, weight loss, and depressive symptomatology. Impaired circadian cortisol periodicity, blunted DST response, and increased β-endorphin plasma levels, observed in a subgroup of patients, could not be related to weight loss, either before or after therapy. Instead, a trend toward a relationship between neuroendocrine impairments and depressive symptoms was observed before and after treatment.

Original languageEnglish
Pages (from-to)165-176
Number of pages12
JournalPsychiatry Research
Volume16
Issue number2
DOIs
Publication statusPublished - 1985

Keywords

  • Anorexia nervosa
  • cortisol secretion
  • desimipramine
  • primary affective disorders
  • β-endorphin
  • β-lipotropin

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Psychology(all)

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