Neuroendocrine and psychopathological measures in anorexia nervosa: Resemblances to primary affective disorders

Francesca Brambilla; Franco Cavagnini; Cecilia Invitti; Franco Poterzio; Mario Lampertico; Laura Sali; Mauricio Maggioni; Carlo Candolfi; Alberto E. Panerai; Eugenio E. Müdler

doi:10.1016/0165-1781(85)90010-1

Neuroendocrine and psychopathological measures in anorexia nervosa: Resemblances to primary affective disorders

Francesca Brambilla, Franco Cavagnini, Cecilia Invitti, Franco Poterzio, Mario Lampertico, Laura Sali, Mauricio Maggioni, Carlo Candolfi, Alberto E. Panerai, Eugenio E. Müdler

Fondazione Istituto Auxologico Italiano

Research output: Contribution to journal › Article › peer-review

Abstract

Clinical and biochemical data suggest a link between anorexia nervosa (AN) and primary affective disorders (PAD). In 14 female patients, aged 15-40 years, with 7-month to 11-year histories of AN, we studied circadian cortisol periodicity, response to the dexamethasone suppression test (DST), and plasma levels of β-endorphin and β-lipotropin before and after desimipramine therapy. Possible correlations were sought among neuroendocrine impairments, weight loss, and depressive symptomatology. Impaired circadian cortisol periodicity, blunted DST response, and increased β-endorphin plasma levels, observed in a subgroup of patients, could not be related to weight loss, either before or after therapy. Instead, a trend toward a relationship between neuroendocrine impairments and depressive symptoms was observed before and after treatment.

Original language	English
Pages (from-to)	165-176
Number of pages	12
Journal	Psychiatry Research
Volume	16
Issue number	2
DOIs	https://doi.org/10.1016/0165-1781(85)90010-1
Publication status	Published - 1985

Keywords

Anorexia nervosa
cortisol secretion
desimipramine
primary affective disorders
β-endorphin
β-lipotropin

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry
Psychology(all)

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Neuroendocrine and psychopathological measures in anorexia nervosa : Resemblances to primary affective disorders. / Brambilla, Francesca; Cavagnini, Franco; Invitti, Cecilia; Poterzio, Franco; Lampertico, Mario; Sali, Laura; Maggioni, Mauricio; Candolfi, Carlo; Panerai, Alberto E.; Müdler, Eugenio E.

In: Psychiatry Research, Vol. 16, No. 2, 1985, p. 165-176.

Research output: Contribution to journal › Article › peer-review

Brambilla, Francesca ; Cavagnini, Franco ; Invitti, Cecilia ; Poterzio, Franco ; Lampertico, Mario ; Sali, Laura ; Maggioni, Mauricio ; Candolfi, Carlo ; Panerai, Alberto E. ; Müdler, Eugenio E. / Neuroendocrine and psychopathological measures in anorexia nervosa : Resemblances to primary affective disorders. In: Psychiatry Research. 1985 ; Vol. 16, No. 2. pp. 165-176.

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abstract = "Clinical and biochemical data suggest a link between anorexia nervosa (AN) and primary affective disorders (PAD). In 14 female patients, aged 15-40 years, with 7-month to 11-year histories of AN, we studied circadian cortisol periodicity, response to the dexamethasone suppression test (DST), and plasma levels of β-endorphin and β-lipotropin before and after desimipramine therapy. Possible correlations were sought among neuroendocrine impairments, weight loss, and depressive symptomatology. Impaired circadian cortisol periodicity, blunted DST response, and increased β-endorphin plasma levels, observed in a subgroup of patients, could not be related to weight loss, either before or after therapy. Instead, a trend toward a relationship between neuroendocrine impairments and depressive symptoms was observed before and after treatment.",

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