TY - JOUR
T1 - Neuroendocrine and psychopathological measures in anorexia nervosa
T2 - Resemblances to primary affective disorders
AU - Brambilla, Francesca
AU - Cavagnini, Franco
AU - Invitti, Cecilia
AU - Poterzio, Franco
AU - Lampertico, Mario
AU - Sali, Laura
AU - Maggioni, Mauricio
AU - Candolfi, Carlo
AU - Panerai, Alberto E.
AU - Müdler, Eugenio E.
PY - 1985
Y1 - 1985
N2 - Clinical and biochemical data suggest a link between anorexia nervosa (AN) and primary affective disorders (PAD). In 14 female patients, aged 15-40 years, with 7-month to 11-year histories of AN, we studied circadian cortisol periodicity, response to the dexamethasone suppression test (DST), and plasma levels of β-endorphin and β-lipotropin before and after desimipramine therapy. Possible correlations were sought among neuroendocrine impairments, weight loss, and depressive symptomatology. Impaired circadian cortisol periodicity, blunted DST response, and increased β-endorphin plasma levels, observed in a subgroup of patients, could not be related to weight loss, either before or after therapy. Instead, a trend toward a relationship between neuroendocrine impairments and depressive symptoms was observed before and after treatment.
AB - Clinical and biochemical data suggest a link between anorexia nervosa (AN) and primary affective disorders (PAD). In 14 female patients, aged 15-40 years, with 7-month to 11-year histories of AN, we studied circadian cortisol periodicity, response to the dexamethasone suppression test (DST), and plasma levels of β-endorphin and β-lipotropin before and after desimipramine therapy. Possible correlations were sought among neuroendocrine impairments, weight loss, and depressive symptomatology. Impaired circadian cortisol periodicity, blunted DST response, and increased β-endorphin plasma levels, observed in a subgroup of patients, could not be related to weight loss, either before or after therapy. Instead, a trend toward a relationship between neuroendocrine impairments and depressive symptoms was observed before and after treatment.
KW - Anorexia nervosa
KW - cortisol secretion
KW - desimipramine
KW - primary affective disorders
KW - β-endorphin
KW - β-lipotropin
UR - http://www.scopus.com/inward/record.url?scp=0022221905&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022221905&partnerID=8YFLogxK
U2 - 10.1016/0165-1781(85)90010-1
DO - 10.1016/0165-1781(85)90010-1
M3 - Article
C2 - 2933758
AN - SCOPUS:0022221905
VL - 16
SP - 165
EP - 176
JO - Psychiatry Research
JF - Psychiatry Research
SN - 0165-1781
IS - 2
ER -