Neuroendocrine carcinoma of the cervix: Review of the literature

Neuroendocrine carcinoma of the cervix is a rare and aggressive tumor associated with an extremely poor prognosis. Even in patients with early stage neoplasia (FIGO I or II), systemic metastases are common, and a cause of death. Flow cytometry demonstrates the aggressive nature of this tumor. A patient with advanced neuroendocrine carcinoma was treated with coral abdominal hysterectomy and bilateral salpingo-oophorectomy. Adjuvant chemotherapy with cisplatin + Ifosfamide was employed; then we used carboplatin, and later bleomycin + methotrexate + cisplatin. The patient died 20 months after the diagnosis.