Neuroendocrine carcinoma of the skin (Merkel cell tumor): Ultrastructural and immunohistochemical study of a case

L. Massone, R. Piccini, L. Borgiani, S. Borghi, A. Pestarino, C. Gambini

Research output: Contribution to journalArticlepeer-review

Abstract

A case of neuroendocrine carcinoma of the skin that developed on the right leg of a 75-year-old woman is reported. The patient, a year after the surgical ablation, developed no recurrence or metastatic lesions. Histopathologic findings showed a prevalent trabecular pattern of the carcinoma. At the ultrastructural level, the tumour cells showed typical neurosecretory granules, intermediate filaments with perinuclear distribution and complex intercellulare junctions. Immunohistochemically, the tumour cells showed positive staining for neuron-specific enolase and for neurofilaments, while low molecular weight cytokeratins (54 kd) reacted only in a few elements. In this paper we discuss the relationship between this tumour and the Merkel cell and we report the most recent hypothesis about the histogenesis of this cell.

Original languageEnglish
Pages (from-to)219-223
Number of pages5
JournalGiornale Italiano di Dermatologia e Venereologia
Volume123
Issue number5
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Dermatology

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