A case of neuroendocrine carcinoma of the skin that developed on the right leg of a 75-year-old woman is reported. The patient, a year after the surgical ablation, developed no recurrence or metastatic lesions. Histopathologic findings showed a prevalent trabecular pattern of the carcinoma. At the ultrastructural level, the tumour cells showed typical neurosecretory granules, intermediate filaments with perinuclear distribution and complex intercellulare junctions. Immunohistochemically, the tumour cells showed positive staining for neuron-specific enolase and for neurofilaments, while low molecular weight cytokeratins (54 kd) reacted only in a few elements. In this paper we discuss the relationship between this tumour and the Merkel cell and we report the most recent hypothesis about the histogenesis of this cell.
|Number of pages||5|
|Journal||Giornale Italiano di Dermatologia e Venereologia|
|Publication status||Published - 1988|
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