Modificazioni neuroendocrine ed invecchiamento

Translated title of the contribution: Neuroendocrine changes and aging

Ettore Ferrari, L. Cravello, S. Chytiris, F. Falvo, S. B. Solerte, M. Fioravanti, F. Magri

Research output: Contribution to journalArticlepeer-review


The neuroendocrine changes occurring with aging, although rarely clinically evident, may, however, play a role in the occurrence and/or in the progression of metabolic, functional and cognitive alterations. The main neuroendocrine changes with a potential pathogenetic role are: 1) melatonin secretion, the principal hormone secreted by the pineal gland, with some possible anti-aging properties, whom secretion shows an evident age-related decline, particularly during night-time; 2) the hypothalamic-pituitary-adrenal axis activity, which undergoes to changes exposing the central nervous system to a neurotoxic steroidal milieu; and 3) the thyroid function, which, due to its importance in homeostasis, has been deeply studied obtaining conflicting results. In this review it will be discussed the role played by these neuroendocrine changes on physiological and pathological aging, on the basis of the literature data and of our personal findings.

Translated title of the contributionNeuroendocrine changes and aging
Original languageItalian
Pages (from-to)528-538
Number of pages11
JournalGiornale di Gerontologia
Issue number6
Publication statusPublished - Dec 2004

ASJC Scopus subject areas

  • Ageing
  • Geriatrics and Gerontology

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