The neuroendocrine changes occurring with aging, although rarely clinically evident, may, however, play a role in the occurrence and/or in the progression of metabolic, functional and cognitive alterations. The main neuroendocrine changes with a potential pathogenetic role are: 1) melatonin secretion, the principal hormone secreted by the pineal gland, with some possible anti-aging properties, whom secretion shows an evident age-related decline, particularly during night-time; 2) the hypothalamic-pituitary-adrenal axis activity, which undergoes to changes exposing the central nervous system to a neurotoxic steroidal milieu; and 3) the thyroid function, which, due to its importance in homeostasis, has been deeply studied obtaining conflicting results. In this review it will be discussed the role played by these neuroendocrine changes on physiological and pathological aging, on the basis of the literature data and of our personal findings.
|Translated title of the contribution||Neuroendocrine changes and aging|
|Number of pages||11|
|Journal||Giornale di Gerontologia|
|Publication status||Published - Dec 2004|
ASJC Scopus subject areas
- Geriatrics and Gerontology