Neuroendocrine differentiation in non-small cell lung carcinomas

Alfonso Baldi, Angela M. Groger, Vincenzo Esposito, Maria Pia Di Marino, Nicola Ferrara, Feliciano Baldi

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The immunohistochemical expression of ten neuroendocrine and neural differentiation-related antigens in 200 specimens from patients with surgically resected non-small cell lung carcinomas were evaluated. Poorly differentiated adenocarcinomas and undifferentiated large cell carcinomas showed the highest percentage of positive samples (30%-60%) for the markers evaluated with diffuse and intense immunostaining. Poorly differentiated squamous carcinomas bronchioalveolar adenocarcinomas, and giant cell carcinomas showed a lower percentage of positive samples (20%) with moderate immunostaining. Well differentiated tumors were very rarely positive for the neuroendocrine markers. It is concluded that neoplasms positive for the neuroendocrine markers can be considered as non-small cell carcinoma with neuroendocrine features, even if they do not have the histological appearance of neuroendocrine lung neoplasms.

Original languageEnglish
Pages (from-to)109-114
Number of pages6
JournalIn Vivo
Volume14
Issue number1
Publication statusPublished - Jan 2000

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Non-Small Cell Lung Carcinoma
Adenocarcinoma
Giant Cell Carcinoma
Cells
Neuroendocrine Carcinoma
Large Cell Carcinoma
Differentiation Antigens
Squamous Cell Carcinoma
Lung Neoplasms
Neoplasms
Tumors
Antigens

Keywords

  • Immunohistochemistry
  • Neuroendocrine marker
  • Non-small cell lung carcinomas

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Baldi, A., Groger, A. M., Esposito, V., Di Marino, M. P., Ferrara, N., & Baldi, F. (2000). Neuroendocrine differentiation in non-small cell lung carcinomas. In Vivo, 14(1), 109-114.

Neuroendocrine differentiation in non-small cell lung carcinomas. / Baldi, Alfonso; Groger, Angela M.; Esposito, Vincenzo; Di Marino, Maria Pia; Ferrara, Nicola; Baldi, Feliciano.

In: In Vivo, Vol. 14, No. 1, 01.2000, p. 109-114.

Research output: Contribution to journalArticle

Baldi, A, Groger, AM, Esposito, V, Di Marino, MP, Ferrara, N & Baldi, F 2000, 'Neuroendocrine differentiation in non-small cell lung carcinomas', In Vivo, vol. 14, no. 1, pp. 109-114.
Baldi A, Groger AM, Esposito V, Di Marino MP, Ferrara N, Baldi F. Neuroendocrine differentiation in non-small cell lung carcinomas. In Vivo. 2000 Jan;14(1):109-114.
Baldi, Alfonso ; Groger, Angela M. ; Esposito, Vincenzo ; Di Marino, Maria Pia ; Ferrara, Nicola ; Baldi, Feliciano. / Neuroendocrine differentiation in non-small cell lung carcinomas. In: In Vivo. 2000 ; Vol. 14, No. 1. pp. 109-114.
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