Neuroendocrine differentiation patterns in various organs (including lung, breast, skin and urogenital tract)

Marco Volante, Anna Sapino, Mauro Papotti, Donatella Pacchioni, Gianni Bussolati

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Tumors with pure or incomplete neuroendocrine phenotype may arise everywhere in the human body, including non-neuroendocrine organs, and share several common ultrastructural, morphological and phenoptypical properties; however, they do not constitute a single, uniform entity, but rather represent a spectrum of lesions in which the degree of neuroendocrine differentiation matches the clinical behavior. This chapter reviews the common diagnostic and classification criteria of these tumors in the lung, breast, skin and urogenital tract, and reports the molecular data that have been related to morphology in order to better understand their histogenesis and biological properties, as well as to identify novel therapeutic targets.

Original languageEnglish
Title of host publicationEndocrine Pathology: Differential Diagnosis and Molecular Advances
PublisherSpringer New York
Pages415-428
Number of pages14
ISBN (Print)9781441910684
DOIs
Publication statusPublished - 2010

Keywords

  • Breast
  • Divergent differentiation
  • Lung
  • Molecular biology
  • Neuroendocrine
  • Skin
  • Tumor
  • Urogenital tract

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Volante, M., Sapino, A., Papotti, M., Pacchioni, D., & Bussolati, G. (2010). Neuroendocrine differentiation patterns in various organs (including lung, breast, skin and urogenital tract). In Endocrine Pathology: Differential Diagnosis and Molecular Advances (pp. 415-428). Springer New York. https://doi.org/10.1007/978-1-4419-1069-1_18