Neuroendocrine evidence of deranged noradrenergic activity in chronic migraine

E. Martignoni, F. Facchinetti, F. Rossi, G. Sances, A. R. Genazzani, G. Nappi

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Migraine is a psychobiological disorder in which a recurrent failure of opioid and adrenergic systems might occur, as plasma and CSF studies suggest. In order to elucidate the relationship between noradrenergic and opioidergic functions, the plasma β-endorphin (β-EP) response to clonidine and the cortisol response to dexamethasone were evaluated together in 25 patients suffering from migraine without aura, and with chronic tension headache (MTH). Baseline β-EP plasma levels and β-EP response to clonidine were significantly lower in MTH subjects than in controls, suggesting a postsynaptic hypothalamo-pituitary impairment. Forty-four percent of the MTH subjects showed either a lack of suppression of plasma cortisol following dexamethasone administration, or basal cortisol concentrations higher than controls and suppressors, suggesting a disinhibition of the hypothalamo-pituitary-adrenal (HPA) axis. An inverse correlation was found between pain severity and β-EP secretion induced by clonidine (Δ max), and no relationship was found between β-EP and mood. These data suggest a failure of central noradrenergic activity, or perhaps an impaired secretion of β-EP not related to HPA axis hyperactivity or to affective state.

Original languageEnglish
Pages (from-to)357-363
Number of pages7
JournalPsychoneuroendocrinology
Volume14
Issue number5
DOIs
Publication statusPublished - 1989

Fingerprint

Migraine Disorders
Clonidine
Hydrocortisone
Dexamethasone
Endorphins
Migraine without Aura
Tension-Type Headache
Headache Disorders
Adrenergic Agents
Opioid Analgesics
Pain

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Psychiatry and Mental health
  • Biological Psychiatry
  • Endocrine and Autonomic Systems
  • Psychology(all)

Cite this

Neuroendocrine evidence of deranged noradrenergic activity in chronic migraine. / Martignoni, E.; Facchinetti, F.; Rossi, F.; Sances, G.; Genazzani, A. R.; Nappi, G.

In: Psychoneuroendocrinology, Vol. 14, No. 5, 1989, p. 357-363.

Research output: Contribution to journalArticle

Martignoni, E, Facchinetti, F, Rossi, F, Sances, G, Genazzani, AR & Nappi, G 1989, 'Neuroendocrine evidence of deranged noradrenergic activity in chronic migraine', Psychoneuroendocrinology, vol. 14, no. 5, pp. 357-363. https://doi.org/10.1016/0306-4530(89)90005-X
Martignoni, E. ; Facchinetti, F. ; Rossi, F. ; Sances, G. ; Genazzani, A. R. ; Nappi, G. / Neuroendocrine evidence of deranged noradrenergic activity in chronic migraine. In: Psychoneuroendocrinology. 1989 ; Vol. 14, No. 5. pp. 357-363.
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