Neuroendocrine late effects after tailored photon radiotherapy for children with low grade gliomas: Long term correlation with tumour and treatment parameters

Deborah Aloi, Liliana Belgioia, Salvina Barra, Flavio Giannelli, Francesca Cavagnetto, Fabio Gallo, Claudia Milanaccio, Maria Luisa Garrè, Sonia Di Profio, Natascia Di Iorgi, Renzo Corvò

Research output: Contribution to journalArticle

Abstract

Purpose To evaluate neuroendocrine late effects in paediatric patients with low grade glioma (LGG) who underwent radiotherapy. Methods and material We performed a retrospective evaluation of 40 children with LGG treated from July 2002 to January 2015 with external radiotherapy. Tumour locations were cerebral hemisphere (n = 2); posterior fossa (n = 15); hypothalamic–pituitary axis (HPA, n = 15); spine (n = 5). Three patients presented a diffuse disease. We looked for a correlation between endocrine toxicity and tumour and treatment parameters. The impact of some clinical and demographic factors on endocrinal and neuro toxicity was evaluated using the log-rank test. Results The median follow-up was 52 months (range: 2–151). Median age at irradiation was 6. The dose to the HPA was significantly associated with endocrine toxicity (P value = 0.0190). Patients who received chemotherapy before radiotherapy and younger patients, showed worse performance status and lower IQ. The 5-year overall survival (OS) and progression free survival (PFS) rates were 94% and 73.7%, respectively. Conclusion Radiotherapy showed excellent OS and PFS rates and acceptable late neuroendocrine toxicity profile in this population of LGG patients treated over a period of 13 years. In our experience, the dose to the HPA was predictive of the risk of late endocrine toxicity.

Original languageEnglish
Pages (from-to)241-247
Number of pages7
JournalRadiotherapy and Oncology
Volume125
Issue number2
DOIs
Publication statusPublished - Nov 1 2017

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Photons
Glioma
Radiotherapy
Neoplasms
Disease-Free Survival
Survival Rate
Therapeutics
Survival
Cerebrum
Spine
Demography
Pediatrics
Drug Therapy
Population

Keywords

  • Low grade gliomas
  • Neuroendocrine late toxicity
  • Paediatric tumours
  • Radiotherapy

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Radiology Nuclear Medicine and imaging

Cite this

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title = "Neuroendocrine late effects after tailored photon radiotherapy for children with low grade gliomas: Long term correlation with tumour and treatment parameters",
abstract = "Purpose To evaluate neuroendocrine late effects in paediatric patients with low grade glioma (LGG) who underwent radiotherapy. Methods and material We performed a retrospective evaluation of 40 children with LGG treated from July 2002 to January 2015 with external radiotherapy. Tumour locations were cerebral hemisphere (n = 2); posterior fossa (n = 15); hypothalamic–pituitary axis (HPA, n = 15); spine (n = 5). Three patients presented a diffuse disease. We looked for a correlation between endocrine toxicity and tumour and treatment parameters. The impact of some clinical and demographic factors on endocrinal and neuro toxicity was evaluated using the log-rank test. Results The median follow-up was 52 months (range: 2–151). Median age at irradiation was 6. The dose to the HPA was significantly associated with endocrine toxicity (P value = 0.0190). Patients who received chemotherapy before radiotherapy and younger patients, showed worse performance status and lower IQ. The 5-year overall survival (OS) and progression free survival (PFS) rates were 94{\%} and 73.7{\%}, respectively. Conclusion Radiotherapy showed excellent OS and PFS rates and acceptable late neuroendocrine toxicity profile in this population of LGG patients treated over a period of 13 years. In our experience, the dose to the HPA was predictive of the risk of late endocrine toxicity.",
keywords = "Low grade gliomas, Neuroendocrine late toxicity, Paediatric tumours, Radiotherapy",
author = "Deborah Aloi and Liliana Belgioia and Salvina Barra and Flavio Giannelli and Francesca Cavagnetto and Fabio Gallo and Claudia Milanaccio and Garr{\`e}, {Maria Luisa} and {Di Profio}, Sonia and {Di Iorgi}, Natascia and Renzo Corv{\`o}",
year = "2017",
month = "11",
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doi = "10.1016/j.radonc.2017.09.034",
language = "English",
volume = "125",
pages = "241--247",
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TY - JOUR

T1 - Neuroendocrine late effects after tailored photon radiotherapy for children with low grade gliomas

T2 - Long term correlation with tumour and treatment parameters

AU - Aloi, Deborah

AU - Belgioia, Liliana

AU - Barra, Salvina

AU - Giannelli, Flavio

AU - Cavagnetto, Francesca

AU - Gallo, Fabio

AU - Milanaccio, Claudia

AU - Garrè, Maria Luisa

AU - Di Profio, Sonia

AU - Di Iorgi, Natascia

AU - Corvò, Renzo

PY - 2017/11/1

Y1 - 2017/11/1

N2 - Purpose To evaluate neuroendocrine late effects in paediatric patients with low grade glioma (LGG) who underwent radiotherapy. Methods and material We performed a retrospective evaluation of 40 children with LGG treated from July 2002 to January 2015 with external radiotherapy. Tumour locations were cerebral hemisphere (n = 2); posterior fossa (n = 15); hypothalamic–pituitary axis (HPA, n = 15); spine (n = 5). Three patients presented a diffuse disease. We looked for a correlation between endocrine toxicity and tumour and treatment parameters. The impact of some clinical and demographic factors on endocrinal and neuro toxicity was evaluated using the log-rank test. Results The median follow-up was 52 months (range: 2–151). Median age at irradiation was 6. The dose to the HPA was significantly associated with endocrine toxicity (P value = 0.0190). Patients who received chemotherapy before radiotherapy and younger patients, showed worse performance status and lower IQ. The 5-year overall survival (OS) and progression free survival (PFS) rates were 94% and 73.7%, respectively. Conclusion Radiotherapy showed excellent OS and PFS rates and acceptable late neuroendocrine toxicity profile in this population of LGG patients treated over a period of 13 years. In our experience, the dose to the HPA was predictive of the risk of late endocrine toxicity.

AB - Purpose To evaluate neuroendocrine late effects in paediatric patients with low grade glioma (LGG) who underwent radiotherapy. Methods and material We performed a retrospective evaluation of 40 children with LGG treated from July 2002 to January 2015 with external radiotherapy. Tumour locations were cerebral hemisphere (n = 2); posterior fossa (n = 15); hypothalamic–pituitary axis (HPA, n = 15); spine (n = 5). Three patients presented a diffuse disease. We looked for a correlation between endocrine toxicity and tumour and treatment parameters. The impact of some clinical and demographic factors on endocrinal and neuro toxicity was evaluated using the log-rank test. Results The median follow-up was 52 months (range: 2–151). Median age at irradiation was 6. The dose to the HPA was significantly associated with endocrine toxicity (P value = 0.0190). Patients who received chemotherapy before radiotherapy and younger patients, showed worse performance status and lower IQ. The 5-year overall survival (OS) and progression free survival (PFS) rates were 94% and 73.7%, respectively. Conclusion Radiotherapy showed excellent OS and PFS rates and acceptable late neuroendocrine toxicity profile in this population of LGG patients treated over a period of 13 years. In our experience, the dose to the HPA was predictive of the risk of late endocrine toxicity.

KW - Low grade gliomas

KW - Neuroendocrine late toxicity

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KW - Radiotherapy

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