Neuroendocrine tumors of the gallbladder: A case report and review of the literature

Silvia Mezi, Vincenzo Petrozza, Orazio Schillaci, Valentina La Torre, Barbara Cimadon, Martina Leopizzi, Errico Orsi, Filippo La Torre

Research output: Contribution to journalArticle

Abstract

Introduction. Primary gallbladder neuroendocrine tumors are extremely rare, representing 0.2% of all neuroendocrine tumors. The diagnosis is incidental in most cases. Case presentation. We describe the case of a 57-year-old Caucasian man who underwent laparoscopic cholecystectomy for the evaluation of a gallbladder polyp that had been incidentally detected by ultasonography. Histologically, his lesion was composed of monomorphic cells that contained small round nuclei and that were organized in small nodular, trabecular, and acinar structures. His cells were positive for chromogranin A and synaptophysin, and a diagnosis of "typical" carcinoid of the gallbladder was made. His post-operative computerized axial tomography, 111In-pentetreotide scintigraphy, and hormone-specific marker results were negative. He is disease-free 45 months after surgical treatment. Conclusions: Characteristic pathological findings of the gallbladder neuroendocrine tumors predict the prognosis. Whereas classical carcinoids of the gallbladder only rarely have a metastatic or invasive phenotype, the "atypical" variants are more aggressive and are associated with a poorer prognosis. Given the difficulty in distinguishing between benign and malignant lesions in the pre-surgical setting, we tend to consider each polypoid-like lesion of the gallbladder to be a high-risk lesion if it is larger than 1 cm and, as a result, to emphasize the need for cholecystectomy in all cases, relying on the pathological and immunohistochemistry analyses for the final diagnosis.

Original languageEnglish
Article number334
JournalJournal of Medical Case Reports
Volume5
DOIs
Publication statusPublished - 2011

Fingerprint

Neuroendocrine Tumors
Gallbladder
Carcinoid Tumor
Chromogranin A
Synaptophysin
Laparoscopic Cholecystectomy
Cholecystectomy
Polyps
Radionuclide Imaging
Immunohistochemistry
Tomography
Hormones
Phenotype

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Mezi, S., Petrozza, V., Schillaci, O., La Torre, V., Cimadon, B., Leopizzi, M., ... La Torre, F. (2011). Neuroendocrine tumors of the gallbladder: A case report and review of the literature. Journal of Medical Case Reports, 5, [334]. https://doi.org/10.1186/1752-1947-5-334

Neuroendocrine tumors of the gallbladder : A case report and review of the literature. / Mezi, Silvia; Petrozza, Vincenzo; Schillaci, Orazio; La Torre, Valentina; Cimadon, Barbara; Leopizzi, Martina; Orsi, Errico; La Torre, Filippo.

In: Journal of Medical Case Reports, Vol. 5, 334, 2011.

Research output: Contribution to journalArticle

Mezi, S, Petrozza, V, Schillaci, O, La Torre, V, Cimadon, B, Leopizzi, M, Orsi, E & La Torre, F 2011, 'Neuroendocrine tumors of the gallbladder: A case report and review of the literature', Journal of Medical Case Reports, vol. 5, 334. https://doi.org/10.1186/1752-1947-5-334
Mezi, Silvia ; Petrozza, Vincenzo ; Schillaci, Orazio ; La Torre, Valentina ; Cimadon, Barbara ; Leopizzi, Martina ; Orsi, Errico ; La Torre, Filippo. / Neuroendocrine tumors of the gallbladder : A case report and review of the literature. In: Journal of Medical Case Reports. 2011 ; Vol. 5.
@article{3a219caf21e9467c9f4dbdac25056162,
title = "Neuroendocrine tumors of the gallbladder: A case report and review of the literature",
abstract = "Introduction. Primary gallbladder neuroendocrine tumors are extremely rare, representing 0.2{\%} of all neuroendocrine tumors. The diagnosis is incidental in most cases. Case presentation. We describe the case of a 57-year-old Caucasian man who underwent laparoscopic cholecystectomy for the evaluation of a gallbladder polyp that had been incidentally detected by ultasonography. Histologically, his lesion was composed of monomorphic cells that contained small round nuclei and that were organized in small nodular, trabecular, and acinar structures. His cells were positive for chromogranin A and synaptophysin, and a diagnosis of {"}typical{"} carcinoid of the gallbladder was made. His post-operative computerized axial tomography, 111In-pentetreotide scintigraphy, and hormone-specific marker results were negative. He is disease-free 45 months after surgical treatment. Conclusions: Characteristic pathological findings of the gallbladder neuroendocrine tumors predict the prognosis. Whereas classical carcinoids of the gallbladder only rarely have a metastatic or invasive phenotype, the {"}atypical{"} variants are more aggressive and are associated with a poorer prognosis. Given the difficulty in distinguishing between benign and malignant lesions in the pre-surgical setting, we tend to consider each polypoid-like lesion of the gallbladder to be a high-risk lesion if it is larger than 1 cm and, as a result, to emphasize the need for cholecystectomy in all cases, relying on the pathological and immunohistochemistry analyses for the final diagnosis.",
author = "Silvia Mezi and Vincenzo Petrozza and Orazio Schillaci and {La Torre}, Valentina and Barbara Cimadon and Martina Leopizzi and Errico Orsi and {La Torre}, Filippo",
year = "2011",
doi = "10.1186/1752-1947-5-334",
language = "English",
volume = "5",
journal = "Journal of Medical Case Reports",
issn = "1752-1947",
publisher = "BioMed Central",

}

TY - JOUR

T1 - Neuroendocrine tumors of the gallbladder

T2 - A case report and review of the literature

AU - Mezi, Silvia

AU - Petrozza, Vincenzo

AU - Schillaci, Orazio

AU - La Torre, Valentina

AU - Cimadon, Barbara

AU - Leopizzi, Martina

AU - Orsi, Errico

AU - La Torre, Filippo

PY - 2011

Y1 - 2011

N2 - Introduction. Primary gallbladder neuroendocrine tumors are extremely rare, representing 0.2% of all neuroendocrine tumors. The diagnosis is incidental in most cases. Case presentation. We describe the case of a 57-year-old Caucasian man who underwent laparoscopic cholecystectomy for the evaluation of a gallbladder polyp that had been incidentally detected by ultasonography. Histologically, his lesion was composed of monomorphic cells that contained small round nuclei and that were organized in small nodular, trabecular, and acinar structures. His cells were positive for chromogranin A and synaptophysin, and a diagnosis of "typical" carcinoid of the gallbladder was made. His post-operative computerized axial tomography, 111In-pentetreotide scintigraphy, and hormone-specific marker results were negative. He is disease-free 45 months after surgical treatment. Conclusions: Characteristic pathological findings of the gallbladder neuroendocrine tumors predict the prognosis. Whereas classical carcinoids of the gallbladder only rarely have a metastatic or invasive phenotype, the "atypical" variants are more aggressive and are associated with a poorer prognosis. Given the difficulty in distinguishing between benign and malignant lesions in the pre-surgical setting, we tend to consider each polypoid-like lesion of the gallbladder to be a high-risk lesion if it is larger than 1 cm and, as a result, to emphasize the need for cholecystectomy in all cases, relying on the pathological and immunohistochemistry analyses for the final diagnosis.

AB - Introduction. Primary gallbladder neuroendocrine tumors are extremely rare, representing 0.2% of all neuroendocrine tumors. The diagnosis is incidental in most cases. Case presentation. We describe the case of a 57-year-old Caucasian man who underwent laparoscopic cholecystectomy for the evaluation of a gallbladder polyp that had been incidentally detected by ultasonography. Histologically, his lesion was composed of monomorphic cells that contained small round nuclei and that were organized in small nodular, trabecular, and acinar structures. His cells were positive for chromogranin A and synaptophysin, and a diagnosis of "typical" carcinoid of the gallbladder was made. His post-operative computerized axial tomography, 111In-pentetreotide scintigraphy, and hormone-specific marker results were negative. He is disease-free 45 months after surgical treatment. Conclusions: Characteristic pathological findings of the gallbladder neuroendocrine tumors predict the prognosis. Whereas classical carcinoids of the gallbladder only rarely have a metastatic or invasive phenotype, the "atypical" variants are more aggressive and are associated with a poorer prognosis. Given the difficulty in distinguishing between benign and malignant lesions in the pre-surgical setting, we tend to consider each polypoid-like lesion of the gallbladder to be a high-risk lesion if it is larger than 1 cm and, as a result, to emphasize the need for cholecystectomy in all cases, relying on the pathological and immunohistochemistry analyses for the final diagnosis.

UR - http://www.scopus.com/inward/record.url?scp=79960850985&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79960850985&partnerID=8YFLogxK

U2 - 10.1186/1752-1947-5-334

DO - 10.1186/1752-1947-5-334

M3 - Article

C2 - 21801379

AN - SCOPUS:79960850985

VL - 5

JO - Journal of Medical Case Reports

JF - Journal of Medical Case Reports

SN - 1752-1947

M1 - 334

ER -