TY - JOUR
T1 - Guzy neuroendokrynne jelita cienkiego i wyrostka robaczkowego (zasady postȩpowania rekomendowane przez Polska̧ Sieć Guzów Neuroendokrynnych)
AU - Bolanowski, Marek
AU - Jarza̧b, Barbara
AU - Handkiewicz-Junak, Daria
AU - Jeziorski, Arkadiusz
AU - Kos-Kudła, Beata
AU - Zajȩcki, Wojciech
AU - Bar-Andziak, Ewa
AU - Ćwikła, Jarosław
AU - De Herder, Wouter
AU - Dzielicki, Józef
AU - Falconi, Massimo
AU - Foltyn, Wanda
AU - Gaciong, Zbigniew
AU - Hubalewska-Dydejczyk, Alicja
AU - Kowalska, Aldona
AU - Królicki, Leszek
AU - Krzyzanowska-Świniarska, Barbara
AU - Kryszałowicz, Bozena
AU - Kvols, Larry
AU - Nasierowska-Guttmejer, Anna
AU - O'Toole, Dermot
AU - Kunikowska, Jolanta
AU - Lampe, Paweł
AU - Matyja, Violetta
AU - Mełeń-Mucha, Gabriela
AU - Milewicz, Andrzej
AU - Nowak, Andrzej
AU - Nowakowska-Duława, Ewa
AU - Omyła-Staszewska, Joanna
AU - Paja̧k, Jacek
AU - Rudzki, Sławomir
AU - Rydzewska, Grazyna
AU - Sowiński, Jerzy
AU - Starzyńska, Teresa
AU - Strzelczyk, Janusz
AU - Sworczak, Krzysztof
AU - Syrenicz, Anhelli
AU - Szawłowski, Andrzej
AU - Tomaszewska, Romana A.
AU - Waśko-Czopnik, Dorota
AU - Wroński, Marek
AU - Zemczak, Anna
AU - Zgliczyński, Wojciech
PY - 2008/1
Y1 - 2008/1
N2 - Polish recommendations regarding management of patients suffering from neuroendocrine tumors of small intestine and appendix are presented. Small intestine, especially ileum represent most common origin of these tumors. Majority of them are well differentiated and grow slowly. Rarely, they are less differentiated with fast growth and poor prognosis. Symptoms are atypical, diagnosis could be often accidental. In 4-10% of patients typical symptoms of carcinoid syndrome are present. Chromogranin A is useful in the laboratory diagnostics, and urinary excretion of 5-hydroxyindoloacetic acid is helpuf for the diagnostics and monitoring of the disease. Histopathological diagnostics was extensively described. Ultrasound, colonoscopy, capsule endoscopy, baloon enteroscopy, computed tomography, magnetic resonance and somatostatin analogs scintigraphy could be used for the visualization. The treatment of choice in the neuroendocrine tumors of small intestine and appendix is radical or palliative surgery, if possible using endoscopy. Pharmacotherapy consists of biotherapy and chemotherapy. The crucial in biotherapy is somatostatin analogs application, possible in symptomatic treatment of hormonally functioning tumors. This is treatment of choice in carcinoid crisis. Interferon alfa could be applied because of the same indications as somatostatin analogs, except for carcinoid crisis. Chemotherapy is less successful in disseminated or locally advanced intestinal neuroendocrine tumors, so radioisotope therapy should be considered in each case of unresectable tumor.
AB - Polish recommendations regarding management of patients suffering from neuroendocrine tumors of small intestine and appendix are presented. Small intestine, especially ileum represent most common origin of these tumors. Majority of them are well differentiated and grow slowly. Rarely, they are less differentiated with fast growth and poor prognosis. Symptoms are atypical, diagnosis could be often accidental. In 4-10% of patients typical symptoms of carcinoid syndrome are present. Chromogranin A is useful in the laboratory diagnostics, and urinary excretion of 5-hydroxyindoloacetic acid is helpuf for the diagnostics and monitoring of the disease. Histopathological diagnostics was extensively described. Ultrasound, colonoscopy, capsule endoscopy, baloon enteroscopy, computed tomography, magnetic resonance and somatostatin analogs scintigraphy could be used for the visualization. The treatment of choice in the neuroendocrine tumors of small intestine and appendix is radical or palliative surgery, if possible using endoscopy. Pharmacotherapy consists of biotherapy and chemotherapy. The crucial in biotherapy is somatostatin analogs application, possible in symptomatic treatment of hormonally functioning tumors. This is treatment of choice in carcinoid crisis. Interferon alfa could be applied because of the same indications as somatostatin analogs, except for carcinoid crisis. Chemotherapy is less successful in disseminated or locally advanced intestinal neuroendocrine tumors, so radioisotope therapy should be considered in each case of unresectable tumor.
KW - Appendix
KW - Carcinoid
KW - Diagnostics
KW - Neuroendocrine tumors
KW - Small intestine
KW - Therapy
UR - http://www.scopus.com/inward/record.url?scp=42249099996&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=42249099996&partnerID=8YFLogxK
M3 - Articolo
C2 - 18335403
AN - SCOPUS:42249099996
VL - 59
SP - 87
EP - 96
JO - Endokrynologia Polska
JF - Endokrynologia Polska
SN - 0423-104X
IS - 1
ER -