Neuroendocrinological and clinical data upon trazodone treatment in depressed patients

G. Roccatagliata, G. Murialdo, C. Albano, M. Giovale, C. Zauli, A. Polleri

Research output: Contribution to journalArticlepeer-review

Abstract

Prolactin and somatotropin secretory rhythmicity was studied in 7 inhibited depression male patients, evaluated by the Hamilton Rating Scale for depression, before and after trazodone (400 mg i.v. once daily) treatment. The mean 24-hour hormone levels of the patients were comparable to the controls. Trazodone enhances the prolactin value, increasing chiefly the titres during sleep which were lower in respect to controls before treatment. The drug decreases the mean 24-hour somatotropin levels, mainly the values during sleep. A serotoninergic effect is possibly involved. An improvement of mood has been observed in all cases.

Original languageEnglish
Pages (from-to)259-268
Number of pages10
JournalNeuropsychobiology
Volume8
Issue number5
DOIs
Publication statusPublished - 1982

Keywords

  • Inhibited depression
  • Neuroendocrine rhythms
  • Prolactin
  • Somatotropin
  • Trazodone

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)
  • Psychology(all)

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