Abstract
Prolactin and somatotropin secretory rhythmicity was studied in 7 inhibited depression male patients, evaluated by the Hamilton Rating Scale for depression, before and after trazodone (400 mg i.v. once daily) treatment. The mean 24-hour hormone levels of the patients were comparable to the controls. Trazodone enhances the prolactin value, increasing chiefly the titres during sleep which were lower in respect to controls before treatment. The drug decreases the mean 24-hour somatotropin levels, mainly the values during sleep. A serotoninergic effect is possibly involved. An improvement of mood has been observed in all cases.
| Original language | English |
|---|---|
| Pages (from-to) | 259-268 |
| Number of pages | 10 |
| Journal | Neuropsychobiology |
| Volume | 8 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 1982 |
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Keywords
- Inhibited depression
- Neuroendocrine rhythms
- Prolactin
- Somatotropin
- Trazodone
ASJC Scopus subject areas
- Psychiatry and Mental health
- Biological Psychiatry
- Neuropsychology and Physiological Psychology
- Neuroscience(all)
- Psychology(all)
Cite this
Neuroendocrinological and clinical data upon trazodone treatment in depressed patients. / Roccatagliata, G.; Murialdo, G.; Albano, C.; Giovale, M.; Zauli, C.; Polleri, A.
In: Neuropsychobiology, Vol. 8, No. 5, 1982, p. 259-268.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Neuroendocrinological and clinical data upon trazodone treatment in depressed patients
AU - Roccatagliata, G.
AU - Murialdo, G.
AU - Albano, C.
AU - Giovale, M.
AU - Zauli, C.
AU - Polleri, A.
PY - 1982
Y1 - 1982
N2 - Prolactin and somatotropin secretory rhythmicity was studied in 7 inhibited depression male patients, evaluated by the Hamilton Rating Scale for depression, before and after trazodone (400 mg i.v. once daily) treatment. The mean 24-hour hormone levels of the patients were comparable to the controls. Trazodone enhances the prolactin value, increasing chiefly the titres during sleep which were lower in respect to controls before treatment. The drug decreases the mean 24-hour somatotropin levels, mainly the values during sleep. A serotoninergic effect is possibly involved. An improvement of mood has been observed in all cases.
AB - Prolactin and somatotropin secretory rhythmicity was studied in 7 inhibited depression male patients, evaluated by the Hamilton Rating Scale for depression, before and after trazodone (400 mg i.v. once daily) treatment. The mean 24-hour hormone levels of the patients were comparable to the controls. Trazodone enhances the prolactin value, increasing chiefly the titres during sleep which were lower in respect to controls before treatment. The drug decreases the mean 24-hour somatotropin levels, mainly the values during sleep. A serotoninergic effect is possibly involved. An improvement of mood has been observed in all cases.
KW - Inhibited depression
KW - Neuroendocrine rhythms
KW - Prolactin
KW - Somatotropin
KW - Trazodone
UR - http://www.scopus.com/inward/record.url?scp=0019943872&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0019943872&partnerID=8YFLogxK
U2 - 10.1159/000117907
DO - 10.1159/000117907
M3 - Article
C2 - 7133375
AN - SCOPUS:0019943872
VL - 8
SP - 259
EP - 268
JO - Neuropsychobiology
JF - Neuropsychobiology
SN - 0302-282X
IS - 5
ER -