Neuroendocrinological and clinical data upon trazodone treatment in depressed patients

G. Roccatagliata; G. Murialdo; C. Albano; M. Giovale; C. Zauli; A. Polleri

doi:10.1159/000117907

Neuroendocrinological and clinical data upon trazodone treatment in depressed patients

G. Roccatagliata, G. Murialdo, C. Albano, M. Giovale, C. Zauli, A. Polleri

A.O.U. San Martino - IST, Istituto Nazionale Ricerca sul Cancro (GENOVA)

Research output: Contribution to journal › Article › peer-review

Abstract

Prolactin and somatotropin secretory rhythmicity was studied in 7 inhibited depression male patients, evaluated by the Hamilton Rating Scale for depression, before and after trazodone (400 mg i.v. once daily) treatment. The mean 24-hour hormone levels of the patients were comparable to the controls. Trazodone enhances the prolactin value, increasing chiefly the titres during sleep which were lower in respect to controls before treatment. The drug decreases the mean 24-hour somatotropin levels, mainly the values during sleep. A serotoninergic effect is possibly involved. An improvement of mood has been observed in all cases.

Original language	English
Pages (from-to)	259-268
Number of pages	10
Journal	Neuropsychobiology
Volume	8
Issue number	5
DOIs	https://doi.org/10.1159/000117907
Publication status	Published - 1982

Keywords

Inhibited depression
Neuroendocrine rhythms
Prolactin
Somatotropin
Trazodone

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry
Neuropsychology and Physiological Psychology
Neuroscience(all)
Psychology(all)

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AU - Zauli, C.

AU - Polleri, A.

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