Neuroendocrinological and clinical data upon trazodone treatment in depressed patients

G. Roccatagliata; G. Murialdo; C. Albano; M. Giovale; C. Zauli; A. Polleri

doi:10.1159/000117907

Neuroendocrinological and clinical data upon trazodone treatment in depressed patients

G. Roccatagliata, G. Murialdo, C. Albano, M. Giovale, C. Zauli, A. Polleri

A.O.U. San Martino - IST, Istituto Nazionale Ricerca sul Cancro (GENOVA)

Research output: Contribution to journal › Article › peer-review

Abstract

Prolactin and somatotropin secretory rhythmicity was studied in 7 inhibited depression male patients, evaluated by the Hamilton Rating Scale for depression, before and after trazodone (400 mg i.v. once daily) treatment. The mean 24-hour hormone levels of the patients were comparable to the controls. Trazodone enhances the prolactin value, increasing chiefly the titres during sleep which were lower in respect to controls before treatment. The drug decreases the mean 24-hour somatotropin levels, mainly the values during sleep. A serotoninergic effect is possibly involved. An improvement of mood has been observed in all cases.

Original language	English
Pages (from-to)	259-268
Number of pages	10
Journal	Neuropsychobiology
Volume	8
Issue number	5
DOIs	https://doi.org/10.1159/000117907
Publication status	Published - 1982

Keywords

Inhibited depression
Neuroendocrine rhythms
Prolactin
Somatotropin
Trazodone

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry
Neuropsychology and Physiological Psychology
Neuroscience(all)
Psychology(all)

Access to Document

10.1159/000117907

Cite this

@article{998d158101c343748564477001baa469,

title = "Neuroendocrinological and clinical data upon trazodone treatment in depressed patients",

abstract = "Prolactin and somatotropin secretory rhythmicity was studied in 7 inhibited depression male patients, evaluated by the Hamilton Rating Scale for depression, before and after trazodone (400 mg i.v. once daily) treatment. The mean 24-hour hormone levels of the patients were comparable to the controls. Trazodone enhances the prolactin value, increasing chiefly the titres during sleep which were lower in respect to controls before treatment. The drug decreases the mean 24-hour somatotropin levels, mainly the values during sleep. A serotoninergic effect is possibly involved. An improvement of mood has been observed in all cases.",

keywords = "Inhibited depression, Neuroendocrine rhythms, Prolactin, Somatotropin, Trazodone",

author = "G. Roccatagliata and G. Murialdo and C. Albano and M. Giovale and C. Zauli and A. Polleri",

year = "1982",

doi = "10.1159/000117907",

language = "English",

volume = "8",

pages = "259--268",

journal = "Neuropsychobiology",

issn = "0302-282X",

publisher = "S. Karger AG",

number = "5",

}

TY - JOUR

T1 - Neuroendocrinological and clinical data upon trazodone treatment in depressed patients

AU - Roccatagliata, G.

AU - Murialdo, G.

AU - Albano, C.

AU - Giovale, M.

AU - Zauli, C.

AU - Polleri, A.

PY - 1982

Y1 - 1982

N2 - Prolactin and somatotropin secretory rhythmicity was studied in 7 inhibited depression male patients, evaluated by the Hamilton Rating Scale for depression, before and after trazodone (400 mg i.v. once daily) treatment. The mean 24-hour hormone levels of the patients were comparable to the controls. Trazodone enhances the prolactin value, increasing chiefly the titres during sleep which were lower in respect to controls before treatment. The drug decreases the mean 24-hour somatotropin levels, mainly the values during sleep. A serotoninergic effect is possibly involved. An improvement of mood has been observed in all cases.

AB - Prolactin and somatotropin secretory rhythmicity was studied in 7 inhibited depression male patients, evaluated by the Hamilton Rating Scale for depression, before and after trazodone (400 mg i.v. once daily) treatment. The mean 24-hour hormone levels of the patients were comparable to the controls. Trazodone enhances the prolactin value, increasing chiefly the titres during sleep which were lower in respect to controls before treatment. The drug decreases the mean 24-hour somatotropin levels, mainly the values during sleep. A serotoninergic effect is possibly involved. An improvement of mood has been observed in all cases.

KW - Inhibited depression

KW - Neuroendocrine rhythms

KW - Prolactin

KW - Somatotropin

KW - Trazodone

UR - http://www.scopus.com/inward/record.url?scp=0019943872&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019943872&partnerID=8YFLogxK

U2 - 10.1159/000117907

DO - 10.1159/000117907

M3 - Article

C2 - 7133375

AN - SCOPUS:0019943872

VL - 8

SP - 259

EP - 268

JO - Neuropsychobiology

JF - Neuropsychobiology

SN - 0302-282X

IS - 5

ER -

Neuroendocrinological and clinical data upon trazodone treatment in depressed patients

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this