Neurofibromatosis and malignant childhood cancers: a survey in Italy, 1970-83.

M. L. Mosso, M. Castello, F. Fossati Bellani, M. T. Di Tullio, G. Loiacono, G. Paolucci, P. Tamaro, B. Terracini, G. Pastore, F. Loiacono

Research output: Contribution to journalArticlepeer-review

Abstract

Neural tumors, Wilms' tumor, rhabdomyosarcoma and several types of leukemia have been previously described in association with neurofibromatosis (NF). In a nation-wide collection of cases in Italy, 15 children (0-14 years of age) with NF and cancer or leukemia were identified; 13 of them had been diagnosed with cancer between 1976-83. The expected number of children with cancer and NF in 1976-83 was 4.48. The distribution of tumor types was different from that found in the general population, with a higher proportion of tumors of neural crest origin as well as soft tissue sarcomas. In 7/15 the family history was positive for NF; in 5/7 the individuals affected included the mother and/or a maternal relative.

Original languageEnglish
Pages (from-to)209-212
Number of pages4
JournalTumori
Volume73
Issue number3
Publication statusPublished - Jun 30 1987

ASJC Scopus subject areas

  • Cancer Research

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