Neurofunctional correlates of theory of mind deficits in schizophrenia

M. Bosia, R. Riccaboni, S. Poletti

Research output: Contribution to journalArticlepeer-review


Theory of Mind, the ability to understand the potential mental states and intentions of others, represents a relevant aspect of social cognition, with high impact on the capacity to interact within the social world. This very human ability has been one of the focuses of neuroscience research in the past decades and data from neuroimaging studies allowed to identify a Theory of Mind network and to formulate a neurobiological model. Concurrent neuropsychiatric studies showed that Theory of Mind is differently impaired in several conditions, among these, in schizophrenia, a disease characterized by functional and social disability. This paper addresses the issue of neurofunctional correlates of Theory of Mind deficits in schizophrenia, reviewing functional imaging studies of the past ten years comparing schizophrenia patients to healthy controls. Several differences in hemodynamic response between patients and controls were observed in the areas known to be critically involved in social cognition, such as the medial prefrontal cortex, temporal cortex surrounding su- perior temporal sulcus and temporo-parietal junction and cingulate cortex. Results are promising, however they are still heterogeneous. The reported variability could depend on factors related to the construct of Theory of Mind itself, technical aspects and psychopathological/physiopathological mechanisms and needs to be further addressed by future studies.

Original languageEnglish
Pages (from-to)2284-2302
Number of pages19
JournalCurrent Topics in Medicinal Chemistry
Issue number21
Publication statusPublished - 2012


  • Functional magnetic resonance imaging
  • Medial prefrontal cortex
  • Psychosis proneness
  • Schizophrenia
  • Temporo-parietal junction
  • Theory of mind

ASJC Scopus subject areas

  • Drug Discovery


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