TY - JOUR
T1 - Neurofunctional correlates of vulnerability to psychosis
T2 - A systematic review and meta-analysis
AU - Fusar-Poli, Paolo
AU - Perez, Jorge
AU - Broome, Matthew
AU - Borgwardt, Stefan
AU - Placentino, Anna
AU - Caverzasi, Eduardo
AU - Cortesi, Mariachiara
AU - Veggiotti, Pierangelo
AU - Politi, Peirluigi
AU - Barale, Francesco
AU - McGuire, Philip
PY - 2007
Y1 - 2007
N2 - An understanding of the neurobiological correlates of vulnerability to psychosis is fundamental to research on schizophrenia. We systematically reviewed data from studies published from 1992 to 2006 on the neurocognitive correlates (as measured by fMRI) of increased vulnerability to psychosis. We also conducted a meta-analysis of abnormalities of activation in the prefrontal cortex (PFC) in high-risk and first episode subjects, and reviewed neuroimaging studies of high-risk subjects that used PET, SPECT and MRS. Twenty-four original fMRI papers were identified, most of which involved tasks that engaged the PFC. In fMRI studies, vulnerability to psychosis was associated with medium to large effect sizes when prefrontal activation was contrasted with that in controls. Relatives of patients affected with psychosis, the co-twins of patients and subjects with an At Risk Mental State (ARMS) appear to share similar neurocognitive abnormalities. Furthermore, these are qualitatively similar but less severe than those observed in the first episode of illness. These abnormalities have mainly been described in the prefrontal and anterior cingulated cortex, the basal ganglia, hippocampus and cerebellum.
AB - An understanding of the neurobiological correlates of vulnerability to psychosis is fundamental to research on schizophrenia. We systematically reviewed data from studies published from 1992 to 2006 on the neurocognitive correlates (as measured by fMRI) of increased vulnerability to psychosis. We also conducted a meta-analysis of abnormalities of activation in the prefrontal cortex (PFC) in high-risk and first episode subjects, and reviewed neuroimaging studies of high-risk subjects that used PET, SPECT and MRS. Twenty-four original fMRI papers were identified, most of which involved tasks that engaged the PFC. In fMRI studies, vulnerability to psychosis was associated with medium to large effect sizes when prefrontal activation was contrasted with that in controls. Relatives of patients affected with psychosis, the co-twins of patients and subjects with an At Risk Mental State (ARMS) appear to share similar neurocognitive abnormalities. Furthermore, these are qualitatively similar but less severe than those observed in the first episode of illness. These abnormalities have mainly been described in the prefrontal and anterior cingulated cortex, the basal ganglia, hippocampus and cerebellum.
KW - First episode
KW - fMRI
KW - Functional neuroimaging
KW - High-risk
KW - MRS
KW - PET
KW - Psychosis
KW - SPECT
KW - Vulnerability
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U2 - 10.1016/j.neubiorev.2006.11.006
DO - 10.1016/j.neubiorev.2006.11.006
M3 - Article
C2 - 17223194
AN - SCOPUS:34047103295
VL - 31
SP - 465
EP - 484
JO - Neuroscience and Biobehavioral Reviews
JF - Neuroscience and Biobehavioral Reviews
SN - 0149-7634
IS - 4
ER -