Neurofunctional signature of hyperfamiliarity for unknown faces

Elisa Negro, Federico D'Agata, Paola Caroppo, Mario Coriasco, Federica Ferrio, Alessia Celeghin, Matteo Diano, Elisa Rubino, Beatrice De Gelder, Innocenzo Rainero, Lorenzo Pinessi, Marco Tamietto

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Hyperfamiliarity for unknown faces is a rare selective disorder that consists of the disturbing and abnormal feeling of familiarity for unknown faces, while recognition of known faces is normal. In one such patient we investigated with a multimodal neuroimaging design the hitherto undescribed neural signature associated with hyperfamiliarity feelings. Behaviorally, signal detection methods revealed that the patient's discrimination sensitivity between familiar and unfamiliar faces was significantly lower than that of matched controls, and her response criterion for familiarity decisions was significantly more liberal. At the neural level, while morphometric analysis and single-photon emission CT (SPECT) showed the atrophy and hypofunctioning of the left temporal regions, functional magnetic resonance imaging (fMRI) revealed that hyperfamiliarity feelings were selectively associated to enhanced activity in the right medial and inferior temporal cortices. We therefore characterize the neurofunctional signature of hyperfamiliarity for unknown faces as related to the loss of coordinated activity between the complementary face processing functions of the left and right temporal lobes.

Original languageEnglish
Article numbere0129970
JournalPLoS One
Volume10
Issue number7
DOIs
Publication statusPublished - Jul 8 2015

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Neuroimaging
Signal detection
Face recognition
Photons
Temporal Lobe
Processing
Emotions
atrophy
magnetic resonance imaging
Atrophy
Magnetic Resonance Imaging
cortex
Recognition (Psychology)

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Negro, E., D'Agata, F., Caroppo, P., Coriasco, M., Ferrio, F., Celeghin, A., ... Tamietto, M. (2015). Neurofunctional signature of hyperfamiliarity for unknown faces. PLoS One, 10(7), [e0129970]. https://doi.org/10.1371/journal.pone.0129970

Neurofunctional signature of hyperfamiliarity for unknown faces. / Negro, Elisa; D'Agata, Federico; Caroppo, Paola; Coriasco, Mario; Ferrio, Federica; Celeghin, Alessia; Diano, Matteo; Rubino, Elisa; De Gelder, Beatrice; Rainero, Innocenzo; Pinessi, Lorenzo; Tamietto, Marco.

In: PLoS One, Vol. 10, No. 7, e0129970, 08.07.2015.

Research output: Contribution to journalArticle

Negro, E, D'Agata, F, Caroppo, P, Coriasco, M, Ferrio, F, Celeghin, A, Diano, M, Rubino, E, De Gelder, B, Rainero, I, Pinessi, L & Tamietto, M 2015, 'Neurofunctional signature of hyperfamiliarity for unknown faces', PLoS One, vol. 10, no. 7, e0129970. https://doi.org/10.1371/journal.pone.0129970
Negro E, D'Agata F, Caroppo P, Coriasco M, Ferrio F, Celeghin A et al. Neurofunctional signature of hyperfamiliarity for unknown faces. PLoS One. 2015 Jul 8;10(7). e0129970. https://doi.org/10.1371/journal.pone.0129970
Negro, Elisa ; D'Agata, Federico ; Caroppo, Paola ; Coriasco, Mario ; Ferrio, Federica ; Celeghin, Alessia ; Diano, Matteo ; Rubino, Elisa ; De Gelder, Beatrice ; Rainero, Innocenzo ; Pinessi, Lorenzo ; Tamietto, Marco. / Neurofunctional signature of hyperfamiliarity for unknown faces. In: PLoS One. 2015 ; Vol. 10, No. 7.
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