Neurogenic model of migraine

M. G. Buzzi, M. Bonamini, M. A. Moskowitz

Research output: Contribution to journalArticlepeer-review

Abstract

Activation of peripheral trigeminal fibers induces neurogenic inflammation in rat dura mater, as well as vascular and mast cell changes. These changes parallel an increase of vasodilating and permeability promoting peptides in venous effluent of the cephalic circulation. The experimental model of electrical trigeminal ganglion stimulation or systemic capsaicin administration has proven effective in detecting cellular activation in brainstem trigeminal nuclei. Animal experimental models of trigeminovascular activation and the effects of antimigraine drugs on functional and morphological consequences of such activation provide the background for further models and for developing pharmacological strategies in this field.

Original languageEnglish
Pages (from-to)277-280
Number of pages4
JournalCephalalgia
Volume15
Issue number4
Publication statusPublished - 1995

Keywords

  • antimigraine drugs
  • neurogenic inflammation
  • trigeminovascular system

ASJC Scopus subject areas

  • Clinical Neurology

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